Literature DB >> 23913777

Discovery of McbB, an enzyme catalyzing the β-carboline skeleton construction in the marinacarboline biosynthetic pathway.

Qi Chen1, Changtao Ji, Yongxiang Song, Hongbo Huang, Junying Ma, Xinpeng Tian, Jianhua Ju.   

Abstract

Three genes, mcbABC, that drive the biosynthesis of marinacarbolines, have been elucidated through genome mining, gene inactivation, heterologous expression, feeding, and site-directed mutagenesis experiments. McbB is highlighted as a novel enzyme for the β-carboline core construction, which involves a Pictet-Spengler cyclization process and requiring E97 for biochemical activity.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Pictet-Spengler reaction; biosynthesis; marinacarbolines; natural products; β-carbolines

Mesh：

Substances：

Year:  2013        PMID： 23913777     DOI： 10.1002/anie.201303449

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  23 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-24       Impact factor: 11.205

7.  Expression, crystallization and preliminary X-ray analysis of McbB, a multifunctional enzyme involved in β-carboline skeleton biosynthesis.

Authors:  Hua Wang; Huaidong Zhang; Yanling Mi; Jianhua Ju; Qi Chen; Houjin Zhang
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-09-25       Impact factor: 1.056

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Journal:  J Nat Prod       Date:  2017-01-27       Impact factor: 4.050

9.  Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines.

Authors:  Benjamin R Lichman; Jianxiong Zhao; Helen C Hailes; John M Ward
Journal:  Nat Commun       Date:  2017-04-03       Impact factor: 14.919

10.  The Broad Aryl Acid Specificity of the Amide Bond Synthetase McbA Suggests Potential for the Biocatalytic Synthesis of Amides.

Authors:  Mark Petchey; Anibal Cuetos; Benjamin Rowlinson; Stephanie Dannevald; Amina Frese; Peter W Sutton; Sarah Lovelock; Richard C Lloyd; Ian J S Fairlamb; Gideon Grogan
Journal:  Angew Chem Int Ed Engl       Date:  2018-08-07       Impact factor: 15.336
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