Literature DB >> 23913698

Covalent small-molecule-RNA complex formation enables cellular profiling of small-molecule-RNA interactions.

Lirui Guan1, Matthew D Disney.   

Abstract

Won't let you go! A strategy is described to design small molecules that react with their cellular RNA targets. This approach not only improves the activity of compounds targeting RNA in cell culture by a factor of about 2500 but also enables cell-wide profiling of its RNA targets.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  RNA; RNA recognition; bioorganic chemistry; chemical biology; nucleic acids

Mesh：

Substances：

Year:  2013        PMID： 23913698      PMCID： PMC3876275          DOI： 10.1002/anie.201301639

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  27 in total

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2.  Chlorambucil in treatment of chronic lymphocytic leukemia and certain lymphomas.

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3.  Factors influencing the extent and selectivity of alkylation within triplexes by reactive G/A motif oligonucleotides.

Authors:  J N Lampe; I V Kutyavin; R Rhinehart; M W Reed; R B Meyer; H B Gamper
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5.  A small molecule microarray platform to select RNA internal loop-ligand interactions.

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Journal:  ACS Chem Biol       Date:  2007-11-02       Impact factor: 5.100

6.  RNA-selective modification by a platinum(II) complex conjugated to amino- and guanidinoglycosides.

Authors:  Jürgen Boer; Kenneth F Blount; Nathan W Luedtke; Lev Elson-Schwab; Yitzhak Tor
Journal:  Angew Chem Int Ed Engl       Date:  2005-01-28       Impact factor: 15.336

7.  Myotonic dystrophy type 1 is associated with nuclear foci of mutant RNA, sequestration of muscleblind proteins and deregulated alternative splicing in neurons.

Authors:  Hong Jiang; Ami Mankodi; Maurice S Swanson; Richard T Moxley; Charles A Thornton
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8.  Defective mRNA in myotonic dystrophy accumulates at the periphery of nuclear splicing speckles.

Authors:  Ian Holt; Saloni Mittal; Denis Furling; Gillian S Butler-Browne; J David Brook; Glenn E Morris
Journal:  Genes Cells       Date:  2007-09       Impact factor: 1.891

9.  Alkylation of guanosine by phosphoramide mustard, chloromethine hydrochloride and chlorambucil.

Authors:  S Kallama; K Hemminki
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1984-03

10.  Small-molecule-mediated cleavage of RNA in living cells.

Authors:  Lirui Guan; Matthew D Disney
Journal:  Angew Chem Int Ed Engl       Date:  2012-12-20       Impact factor: 15.336
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  34 in total

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Journal:  J Vis Exp       Date:  2016-01-20       Impact factor: 1.355

2.  Identifying and validating small molecules interacting with RNA (SMIRNAs).

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3.  Mapping polyamide-DNA interactions in human cells reveals a new design strategy for effective targeting of genomic sites.

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4.  A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence.

Authors:  Jessica L Childs-Disney; Tuan Tran; Balayeshwanth R Vummidi; Sai Pradeep Velagapudi; Hafeez S Haniff; Yasumasa Matsumoto; Gogce Crynen; Mark R Southern; Avik Biswas; Zi-Fu Wang; Timothy L Tellinghuisen; Matthew D Disney
Journal:  Chem       Date:  2018-09-13       Impact factor: 22.804

5.  Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing.

Authors:  Jonathan L Chen; Peiyuan Zhang; Masahito Abe; Haruo Aikawa; Liying Zhang; Alexander J Frank; Timothy Zembryski; Christopher Hubbs; HaJeung Park; Jane Withka; Claire Steppan; Lucy Rogers; Shawn Cabral; Martin Pettersson; Travis T Wager; Matthew A Fountain; Gavin Rumbaugh; Jessica L Childs-Disney; Matthew D Disney
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Review 6.  Approaches to Validate and Manipulate RNA Targets with Small Molecules in Cells.

Authors:  Jessica L Childs-Disney; Matthew D Disney
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-10-22       Impact factor: 13.820

7.  Inhibition of Non-ATG Translational Events in Cells via Covalent Small Molecules Targeting RNA.

Authors:  Wang-Yong Yang; Henry D Wilson; Sai Pradeep Velagapudi; Matthew D Disney
Journal:  J Am Chem Soc       Date:  2015-04-15       Impact factor: 15.419

8.  Small Molecule Recognition and Tools to Study Modulation of r(CGG)(exp) in Fragile X-Associated Tremor Ataxia Syndrome.

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9.  Small molecule-RNA targeting: starting with the fundamentals.

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10.  Precise small-molecule recognition of a toxic CUG RNA repeat expansion.

Authors:  Suzanne G Rzuczek; Lesley A Colgan; Yoshio Nakai; Michael D Cameron; Denis Furling; Ryohei Yasuda; Matthew D Disney
Journal:  Nat Chem Biol       Date:  2016-12-12       Impact factor: 15.040
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