| Literature DB >> 23910084 |
Borhane Guezguez1, Clinton J V Campbell, Allison L Boyd, Francis Karanu, Fanny L Casado, Christine Di Cresce, Tony J Collins, Zoya Shapovalova, Anargyros Xenocostas, Mickie Bhatia.
Abstract
Numerous studies have shown that the bone marrow (BM) niche plays a key role in mouse hematopoietic stem cell (HSC) function and involves contributions from a broad array of cell types. However, the composition and role of the human BM HSC niche have not been investigated. Here, using human bone biopsy specimens, we provide evidence of HSC propensity to localize to endosteal regions of the trabecular bone area (TBA). Through functional xenograft transplantation, we found that human HSCs localizing to the TBA have superior regenerative and self-renewal capacity and are molecularly distinct from those localizing to the long bone area (LBA). In addition, osteoblasts in the TBA possess unique characteristics and express a key network of factors that regulate TBA- versus LBA-localized human HSCs in vivo. Our study reveals that BM localization and architecture play a critical role in defining the functional and molecular properties of human HSCs.Entities:
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Year: 2013 PMID： 23910084 DOI： 10.1016/j.stem.2013.06.015
Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633