The Interaction Between Niche and Hematopoietic Stem Cells.

Hematopoietic stem cells (HSCs) are one of the somatic stem cells that have the ability to regenerate the entire blood system in a hierarchical way for the duration of an adult life. HSCs reside in the bone marrow niche which contain different cells and molecules that regulate the balance of HSC dormancy and activation. Here, we describe the interaction between HSCs and their niche, in particularly the involvement of some signaling pathway. Insights into the hematopoietic microenvironment will help to obtain a better understanding of normal hematopoiesis and how environmental factors affect these processes.