Literature DB >> 25252682

Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human.

Rahul Kushwah1, Borhane Guezguez1, Jung Bok Lee1, Claudia I Hopkins1, Mickie Bhatia2.   

Abstract

The Notch signaling pathway is evolutionarily conserved across species and plays an important role in regulating cell differentiation, proliferation, and survival. It has been implicated in several different hematopoietic processes including early hematopoietic development as well as adult hematological malignancies in humans. This review focuses on recent developments in understanding the role of Notch signaling in the human hematopoietic system with an emphasis on hematopoietic initiation from human pluripotent stem cells and regulation within the bone marrow. Based on recent insights, we summarize potential strategies for treatment of human hematological malignancies toward the concept of targeting Notch signaling for fate regulation.
© 2014 The Authors.

Entities:  

Keywords:  Notch; hematopoiesis; human pluripotent stem cells; leukemia

Mesh：

Substances：

Year:  2014        PMID： 25252682      PMCID： PMC4253487          DOI： 10.15252/embr.201438842

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  104 in total

1.  Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells.

Authors:  Kenji Tanigaki; Hua Han; Norio Yamamoto; Kei Tashiro; Masaya Ikegawa; Kazuki Kuroda; Akira Suzuki; Toru Nakano; Tasuku Honjo
Journal:  Nat Immunol       Date:  2002-04-22       Impact factor: 25.606

2.  Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

Authors:  Takahiro Maeda; Taha Merghoub; Robin M Hobbs; Lin Dong; Manami Maeda; Johannes Zakrzewski; Marcel R M van den Brink; Arthur Zelent; Hirokazu Shigematsu; Koichi Akashi; Julie Teruya-Feldstein; Giorgio Cattoretti; Pier Paolo Pandolfi
Journal:  Science       Date:  2007-05-11       Impact factor: 47.728

3.  MRK003, a γ-secretase inhibitor exhibits promising in vitro pre-clinical activity in multiple myeloma and non-Hodgkin's lymphoma.

Authors:  V Ramakrishnan; S Ansell; J Haug; D Grote; T Kimlinger; M Stenson; M Timm; L Wellik; T Halling; S V Rajkumar; S Kumar
Journal:  Leukemia       Date:  2011-08-09       Impact factor: 11.528

4.  T lineage differentiation from human embryonic stem cells.

Authors:  Zoran Galic; Scott G Kitchen; Amelia Kacena; Aparna Subramanian; Bryan Burke; Ruth Cortado; Jerome A Zack
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-14       Impact factor: 11.205

5.  In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells.

Authors:  Giovanni Amabile; Robert S Welner; Cesar Nombela-Arrieta; Anna Morena D'Alise; Annalisa Di Ruscio; Alexander K Ebralidze; Yevgenya Kraytsberg; Min Ye; Olivier Kocher; Donna S Neuberg; Konstantin Khrapko; Leslie E Silberstein; Daniel G Tenen
Journal:  Blood       Date:  2012-12-04       Impact factor: 22.113

6.  Hematopoietic, angiogenic and eye defects in Meis1 mutant animals.

Authors:  Tomoyuki Hisa; Sally E Spence; Rivka A Rachel; Masami Fujita; Takuro Nakamura; Jerrold M Ward; Deborah E Devor-Henneman; Yuriko Saiki; Haruo Kutsuna; Lino Tessarollo; Nancy A Jenkins; Neal G Copeland
Journal:  EMBO J       Date:  2004-01-08       Impact factor: 11.598

7.  Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

Authors:  Ivan Maillard; Andrew P Weng; Andrea C Carpenter; Carlos G Rodriguez; Hong Sai; Lanwei Xu; David Allman; Jon C Aster; Warren S Pear
Journal:  Blood       Date:  2004-06-08       Impact factor: 22.113

8.  Wnt, activin, and BMP signaling regulate distinct stages in the developmental pathway from embryonic stem cells to blood.

Authors:  M Cristina Nostro; Xin Cheng; Gordon M Keller; Paul Gadue
Journal:  Cell Stem Cell       Date:  2008-01-10       Impact factor: 24.633

9.  TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms.

Authors:  L W Ellisen; J Bird; D C West; A L Soreng; T C Reynolds; S D Smith; J Sklar
Journal:  Cell       Date:  1991-08-23       Impact factor: 41.582

10.  Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia.

Authors:  D Koyama; J Kikuchi; N Hiraoka; T Wada; H Kurosawa; S Chiba; Y Furukawa
Journal:  Leukemia       Date:  2013-12-04       Impact factor: 11.528
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  12 in total

Review 1.  Next-generation sequencing-based panel testing for myeloid neoplasms.

Authors:  Frank C Kuo; Fei Dong
Journal:  Curr Hematol Malig Rep       Date:  2015-06       Impact factor: 3.952

Review 2.  Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders.

Authors:  Mark Y Chiang; Vedran Radojcic; Ivan Maillard
Journal:  Curr Opin Hematol       Date:  2016-07       Impact factor: 3.284

3.  Notch signaling pathway promotes osteogenic differentiation of mesenchymal stem cells by enhancing BMP9/Smad signaling.

Authors:  Junjie Cao; Yalin Wei; Jing Lian; Lunyun Yang; Xiaoyan Zhang; Jiaying Xie; Qiang Liu; Jinyong Luo; Baicheng He; Min Tang
Journal:  Int J Mol Med       Date:  2017-06-22       Impact factor: 4.101

4.  miR-494-3p is a novel tumor driver of lung carcinogenesis.

Authors:  Alice Faversani; Stefano Amatori; Claudia Augello; Federico Colombo; Laura Porretti; Mirco Fanelli; Stefano Ferrero; Alessandro Palleschi; Pier Giuseppe Pelicci; Elena Belloni; Giulia Ercoli; Anna Degrassi; Marco Baccarin; Dario C Altieri; Valentina Vaira; Silvano Bosari
Journal:  Oncotarget       Date:  2017-01-31

5.  Stereotypical architecture of the stem cell niche is spatiotemporally established by miR-125-dependent coordination of Notch and steroid signaling.

Authors:  Andriy S Yatsenko; Halyna R Shcherbata
Journal:  Development       Date:  2018-02-08       Impact factor: 6.868

Review 6.  New Perspectives on Diagnosis and Therapy of Malignant Pleural Mesothelioma.

Authors:  Marika Rossini; Paola Rizzo; Ilaria Bononi; Anthony Clementz; Roberto Ferrari; Fernanda Martini; Mauro G Tognon
Journal:  Front Oncol       Date:  2018-04-03       Impact factor: 6.244

Review 7.  Identification, Culture and Targeting of Cancer Stem Cells.

Authors:  Alejandro Herreros-Pomares
Journal:  Life (Basel)       Date:  2022-01-27

8.  Control of Neural Daughter Cell Proliferation by Multi-level Notch/Su(H)/E(spl)-HLH Signaling.

Authors:  Caroline Bivik; Ryan B MacDonald; Erika Gunnar; Khalil Mazouni; Francois Schweisguth; Stefan Thor
Journal:  PLoS Genet       Date:  2016-04-12       Impact factor: 5.917

9.  Cellular Reprogramming Allows Generation of Autologous Hematopoietic Progenitors From AML Patients That Are Devoid of Patient-Specific Genomic Aberrations.

Authors:  Kyle R Salci; Jong-Hee Lee; Sarah Laronde; Steve Dingwall; Rahul Kushwah; Aline Fiebig-Comyn; Brian Leber; Ronan Foley; Arianna Dal Cin; Mickie Bhatia
Journal:  Stem Cells       Date:  2015-06       Impact factor: 6.277

Review 10.  Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways.

Authors:  Rolf Marschalek
Journal:  Ann Lab Med       Date:  2016-03       Impact factor: 3.464
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