PURPOSE: To evaluate the feasibility of using MR Elastography (MRE) to monitor tissue coagulation extent during in vivo percutaneous laser ablation of the liver. METHODS: A novel inertial acoustic driver was developed to apply mechanical waves via the ablation instrument. Ablation testing was performed in live juvenile female pigs under anesthesia in a 1.5-T whole-body MRI scanner. RESULTS: The inertial driver produced suitable mechanical wave fields in the liver before, during, and after the laser ablation. During 2-min ablations using 4.5-, 7.5- and 15-W laser power, the stiffness of the lesions changed substantially in response to laser heating, indicative of protein denaturation. After a lethal thermal dose (2-min, 15-W) ablation, lesion stiffness was significantly greater than the baseline values (P < 0.007) and became stiffer over time; the mean stiffness increments from baseline were significantly greater than those after lower dose (2-min, 7.5-W) ablations (64.4% vs. 22.5%, P = 0.009). CONCLUSION: MRE was shown capable of measuring tissue stiffness changes due to in vivo laser ablation. If confirmed through additional studies, this technology may be useful in clinical tumor ablation to monitor the spatial extent of tissue coagulation.
PURPOSE: To evaluate the feasibility of using MR Elastography (MRE) to monitor tissue coagulation extent during in vivo percutaneous laser ablation of the liver. METHODS: A novel inertial acoustic driver was developed to apply mechanical waves via the ablation instrument. Ablation testing was performed in live juvenile female pigs under anesthesia in a 1.5-T whole-body MRI scanner. RESULTS: The inertial driver produced suitable mechanical wave fields in the liver before, during, and after the laser ablation. During 2-min ablations using 4.5-, 7.5- and 15-W laser power, the stiffness of the lesions changed substantially in response to laser heating, indicative of protein denaturation. After a lethal thermal dose (2-min, 15-W) ablation, lesion stiffness was significantly greater than the baseline values (P < 0.007) and became stiffer over time; the mean stiffness increments from baseline were significantly greater than those after lower dose (2-min, 7.5-W) ablations (64.4% vs. 22.5%, P = 0.009). CONCLUSION: MRE was shown capable of measuring tissue stiffness changes due to in vivo laser ablation. If confirmed through additional studies, this technology may be useful in clinical tumor ablation to monitor the spatial extent of tissue coagulation.
Authors: P Wiggermann; E-M Jung; S Glöckner; P Hoffstetter; W Uller; A Vasilj; A Schreyer; C Stroszczynski Journal: Ultraschall Med Date: 2011-12-09 Impact factor: 6.548
Authors: Yi Wang; Daniel R Ganger; Josh Levitsky; Laura A Sternick; Robert J McCarthy; Zongming E Chen; Charles W Fasanati; Bradley Bolster; Saurabh Shah; Sven Zuehlsdorff; Reed A Omary; Richard L Ehman; Frank H Miller Journal: AJR Am J Roentgenol Date: 2011-03 Impact factor: 3.959
Authors: Christine U Lee; James F Glockner; Kevin J Glaser; Meng Yin; Jun Chen; Akira Kawashima; Bohyun Kim; Walter K Kremers; Richard L Ehman; James M Gloor Journal: Acad Radiol Date: 2012-04-13 Impact factor: 3.173
Authors: Jun Chen; Jayant A Talwalkar; Meng Yin; Kevin J Glaser; Schuyler O Sanderson; Richard L Ehman Journal: Radiology Date: 2011-04-01 Impact factor: 11.105
Authors: Kenneth R Thomson; Wa Cheung; Samantha J Ellis; Dean Federman; Helen Kavnoudias; Deirdre Loader-Oliver; Stuart Roberts; Peter Evans; Christine Ball; Andrew Haydon Journal: J Vasc Interv Radiol Date: 2011-03-25 Impact factor: 3.464
Authors: Meng Yin; Jayant A Talwalkar; Kevin J Glaser; Armando Manduca; Roger C Grimm; Phillip J Rossman; Jeff L Fidler; Richard L Ehman Journal: Clin Gastroenterol Hepatol Date: 2007-10 Impact factor: 11.382
Authors: Laurent Huwart; Christine Sempoux; Najat Salameh; Jacques Jamart; Laurence Annet; Ralph Sinkus; Frank Peeters; Leon C ter Beek; Yves Horsmans; Bernard E Van Beers Journal: Radiology Date: 2007-11 Impact factor: 11.105
Authors: Gary Y Hou; Jean Provost; Julien Grondin; Shutao Wang; Fabrice Marquet; Ethan Bunting; Elisa E Konofagou Journal: IEEE Trans Med Imaging Date: 2014-06-20 Impact factor: 10.048
Authors: Lorne W Hofstetter; Henrik Odéen; Bradley D Bolster; Alexander Mueller; Douglas A Christensen; Allison Payne; Dennis L Parker Journal: Magn Reson Med Date: 2019-01-21 Impact factor: 4.668
Authors: Lorne W Hofstetter; Henrik Odéen; Bradley D Bolster; Douglas A Christensen; Allison Payne; Dennis L Parker Journal: Phys Med Biol Date: 2021-02-26 Impact factor: 3.609