Literature DB >> 23903523

[Gd(CyPic3A)(H2O)2]-: a stable, bis(aquated) and high-relaxivity Gd(III) complex.

Eric M Gale1, Nathaniel Kenton, Peter Caravan.   

Abstract

We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(III) complexes of hydration state q = 2. [Gd(CyPic3A)(H2O)2](-) affords an r1 value of 5.70 mM(-1) s(-1) at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.

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Year:  2013        PMID： 23903523      PMCID： PMC3791611          DOI： 10.1039/c3cc44116d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  24 in total

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Review 2.  Inorganic and bioinorganic solvent exchange mechanisms.

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3.  Equilibrium and NMR relaxometric studies on the s-triazine-based heptadentate ligand PTDITA showing high selectivity for Gd3+ ions.

Authors:  Zsolt Baranyai; Lorenzo Tei; Giovanni B Giovenzana; Ferenc K Kálmán; Mauro Botta
Journal:  Inorg Chem       Date:  2012-02-07       Impact factor: 5.165

Review 4.  Strategies for increasing the sensitivity of gadolinium based MRI contrast agents.

Authors:  Peter Caravan
Journal:  Chem Soc Rev       Date:  2006-05-03       Impact factor: 54.564

5.  Protein-targeted gadolinium-based magnetic resonance imaging (MRI) contrast agents: design and mechanism of action.

Authors:  Peter Caravan
Journal:  Acc Chem Res       Date:  2009-07-21       Impact factor: 22.384

6.  Thermodynamic stability and kinetic inertness of MS-325, a new blood pool agent for magnetic resonance imaging.

Authors:  P Caravan; C Comuzzi; W Crooks; T J McMurry; G R Choppin; S R Woulfe
Journal:  Inorg Chem       Date:  2001-04-23       Impact factor: 5.165

7.  High relaxivity magnetic resonance imaging contrast agents. Part 1. Impact of single donor atom substitution on relaxivity of serum albumin-bound gadolinium complexes.

Authors:  Stéphane Dumas; Vincent Jacques; Wei-Chuan Sun; Jeffrey S Troughton; Joel T Welch; Jaclyn M Chasse; Heribert Schmitt-Willich; Peter Caravan
Journal:  Invest Radiol       Date:  2010-10       Impact factor: 6.016

8.  Influence of molecular parameters and increasing magnetic field strength on relaxivity of gadolinium- and manganese-based T1 contrast agents.

Authors:  Peter Caravan; Christian T Farrar; Luca Frullano; Ritika Uppal
Journal:  Contrast Media Mol Imaging       Date:  2009 Mar-Apr       Impact factor: 3.161

9.  Physical parameters and biological stability of yttrium(III) diethylenetriaminepentaacetic acid derivative conjugates.

Authors:  T J McMurry; C G Pippin; C Wu; K A Deal; M W Brechbiel; S Mirzadeh; O A Gansow
Journal:  J Med Chem       Date:  1998-08-27       Impact factor: 7.446

10.  Is macrocycle a synonym for kinetic inertness in Gd(III) Complexes? Effect of coordinating and noncoordinating substituents on inertness and relaxivity of Gd(III) chelates with DO3A-like ligands.

Authors:  Miloslav Polasek; Peter Caravan
Journal:  Inorg Chem       Date:  2013-03-21       Impact factor: 5.165
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  8 in total

Review 1.  MR imaging probes: design and applications.

Authors:  Eszter Boros; Eric M Gale; Peter Caravan
Journal:  Dalton Trans       Date:  2015-03-21       Impact factor: 4.390

2.  Probing the structure-relaxivity relationship of bis-hydrated Gd(DOTAla) derivatives.

Authors:  Eszter Boros; Peter Caravan
Journal:  Inorg Chem       Date:  2015-02-18       Impact factor: 5.165

3.  Molecular Magnetic Resonance Imaging with Gd(III)-Based Contrast Agents: Challenges and Key Advances.

Authors:  Hao Li; Thomas J Meade
Journal:  J Am Chem Soc       Date:  2019-10-17       Impact factor: 15.419

Review 4.  Overcoming the concentration-dependence of responsive probes for magnetic resonance imaging.

Authors:  Levi A Ekanger; Matthew J Allen
Journal:  Metallomics       Date:  2015-03       Impact factor: 4.526

Review 5.  Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.

Authors:  Jessica Wahsner; Eric M Gale; Aurora Rodríguez-Rodríguez; Peter Caravan
Journal:  Chem Rev       Date:  2018-10-16       Impact factor: 60.622

Review 6.  Ligand design strategies to increase stability of gadolinium-based magnetic resonance imaging contrast agents.

Authors:  Thomas J Clough; Lijun Jiang; Ka-Leung Wong; Nicholas J Long
Journal:  Nat Commun       Date:  2019-03-29       Impact factor: 14.919

7.  Cyclobutane-Containing Scaffolds as Useful Intermediates in the Stereoselective Synthesis of Suitable Candidates for Biomedical Purposes: Surfactants, Gelators and Metal Cation Ligands.

Authors:  Ona Illa; Albert Serra; Agustí Ardiaca; Xavier Herrero; Guillem Closa; Rosa M Ortuño
Journal:  Int J Mol Sci       Date:  2019-09-04       Impact factor: 5.923

8.  Surprising Complexity of the [Gd(AAZTA)(H2O)2]- Chelate Revealed by NMR in the Frequency and Time Domains.

Authors:  Daniela Lalli; Fabio Carniato; Lorenzo Tei; Carlos Platas-Iglesias; Mauro Botta
Journal:  Inorg Chem       Date:  2021-12-10       Impact factor: 5.165
  8 in total

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