Literature DB >> 23899011

Efficient identification of equivalences in dynamic graphs and pedigree structures.

Hoyt Koepke1, Elizabeth Thompson.   

Abstract

We propose a new framework for designing test and query functions for complex structures that vary across a given parameter such as genetic marker position. The operations we are interested in include equality testing, set operations, isolating unique states, duplication counting, or finding equivalence classes under identifiability constraints. A motivating application is locating equivalence classes in identity-by-descent (IBD) graphs, which are graph structures in pedigree analysis that change over genetic marker location. The nodes of these graphs are unlabeled and identified only by their connecting edges, a constraint easily handled by our approach. The general framework introduced is powerful enough to build a range of testing functions for IBD graphs, dynamic populations, and other structures using a minimal set of operations. The theoretical and algorithmic properties of our approach are analyzed and proved. Computational results on several simulations demonstrate the effectiveness of our approach.

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Year:  2013        PMID: 23899011      PMCID: PMC3728728          DOI: 10.1089/cmb.2013.0032

Source DB:  PubMed          Journal:  J Comput Biol        ISSN: 1066-5277            Impact factor:   1.479


  13 in total

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Authors:  Elizabeth E Marchani; Ellen M Wijsman
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2.  Computationally efficient multipoint linkage analysis on extended pedigrees for trait models with two contributing major Loci.

Authors:  Ming Su; Elizabeth A Thompson
Journal:  Genet Epidemiol       Date:  2012-06-27       Impact factor: 2.135

3.  High-resolution detection of identity by descent in unrelated individuals.

Authors:  Sharon R Browning; Brian L Browning
Journal:  Am J Hum Genet       Date:  2010-03-18       Impact factor: 11.025

Review 4.  A random walk method for computing genetic location scores.

Authors:  K Lange; E Sobel
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

5.  The structure of genetic linkage data: from LIPED to 1M SNPs.

Authors:  Elizabeth Thompson
Journal:  Hum Hered       Date:  2011-07-06       Impact factor: 0.444

6.  Descent graphs in pedigree analysis: applications to haplotyping, location scores, and marker-sharing statistics.

Authors:  E Sobel; K Lange
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

7.  Parametric and nonparametric linkage analysis: a unified multipoint approach.

Authors:  L Kruglyak; M J Daly; M P Reeve-Daly; E S Lander
Journal:  Am J Hum Genet       Date:  1996-06       Impact factor: 11.025

8.  A general model for the genetic analysis of pedigree data.

Authors:  R C Elston; J Stewart
Journal:  Hum Hered       Date:  1971       Impact factor: 0.444

9.  Construction of multilocus genetic linkage maps in humans.

Authors:  E S Lander; P Green
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

10.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

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  5 in total

1.  PBAP: a pipeline for file processing and quality control of pedigree data with dense genetic markers.

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Journal:  Bioinformatics       Date:  2015-07-30       Impact factor: 6.937

2.  Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease.

Authors:  E E Blue; C-E Yu; T A Thornton; N H Chapman; E Kernfeld; N Jiang; K M Shively; K J Buckingham; C T Marvin; M J Bamshad; T D Bird; E M Wijsman
Journal:  Genes Brain Behav       Date:  2017-11-20       Impact factor: 3.449

3.  Visualization of haplotype sharing patterns in pedigree samples.

Authors:  Sulgi Kim; Mohamad Saad; Debby W Tsuang; Ellen M Wijsman
Journal:  Hum Hered       Date:  2014-06-21       Impact factor: 0.444

4.  Pedigree-Free Descent-Based Gene Mapping from Population Samples.

Authors:  Chris Glazner; Elizabeth Thompson
Journal:  Hum Hered       Date:  2015-07-24       Impact factor: 0.444

5.  Identity-by-descent estimation with population- and pedigree-based imputation in admixed family data.

Authors:  Mohamad Saad; Alejandro Q Nato; Fiona L Grimson; Steven M Lewis; Lisa A Brown; Elizabeth M Blue; Timothy A Thornton; Elizabeth A Thompson; Ellen M Wijsman
Journal:  BMC Proc       Date:  2016-10-18
  5 in total

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