Margaret M Byrne1,2, Stacey L Tannenbaum2, Stefan Glück3, Judith Hurley3, Michael Antoni4. 1. Department of Public Health Sciences (MMB), University of Miami Miller School of Medicine, Miami, Florida. 2. Sylvester Comprehensive Cancer Center (MMB, SLT), University of Miami Miller School of Medicine, Miami, Florida. 3. Department of Medicine (SG, JH), University of Miami Miller School of Medicine, Miami, Florida. 4. Department of Psychology, Universityof Miami, Miami, Florida (MA)
Abstract
BACKGROUND: Participation in cancer clinical trials is low, particularly in racial and ethnic minorities in some cases, which has negative consequences for the generalizability for study findings. The objective of this study was to determine what factors are associated with patients' participation or willingness to participate and whether these factors vary by race/ethnicity. DESIGN: or METHODS: . White, Hispanic, and black participants were obtained through the Florida cancer registry and who were diagnosed with breast, lung, colorectal, or prostate cancer (N = 1100). Participants were surveyed via telephone to obtain demographic information, past participation, and willingness to participate in clinical trials, as well as barriers and facilitators to participation. Logistic and Poisson regressions were performed. RESULTS: . Respondents were on average 67.4 years old, 42.7% were male, and 50.1% were married. In this population, 7.7% of respondents had participated in a clinical trial, and 36.5% stated that they would be willing to participate. In multivariate models, blacks and Hispanics were equally likely as whites to be willing to participate in cancer trials, but Hispanics were less likely to have participated, and this was especially more likely in non-English-speaking Hispanics compared with English-speaking Hispanics. Notable barriers across race/ethnicity were mistrust and lack of knowledge of clinical trials. Limitations. Cross-sectional design limits cause-and-effect conclusions. CONCLUSIONS: . There are racial differences in participation rates but not in willingness to participate. We hypothesize that willingness to participate is not very high because people are uninformed about participating, particularly in non-English-speaking Hispanics. Barriers and facilitators to participation vary by race. Improved understanding of cultural differences that can be addressed by physicians may restore faith, comprehension, and acceptability of clinical trials by all patients.
BACKGROUND: Participation in cancer clinical trials is low, particularly in racial and ethnic minorities in some cases, which has negative consequences for the generalizability for study findings. The objective of this study was to determine what factors are associated with patients' participation or willingness to participate and whether these factors vary by race/ethnicity. DESIGN: or METHODS: . White, Hispanic, and black participants were obtained through the Florida cancer registry and who were diagnosed with breast, lung, colorectal, or prostate cancer (N = 1100). Participants were surveyed via telephone to obtain demographic information, past participation, and willingness to participate in clinical trials, as well as barriers and facilitators to participation. Logistic and Poisson regressions were performed. RESULTS: . Respondents were on average 67.4 years old, 42.7% were male, and 50.1% were married. In this population, 7.7% of respondents had participated in a clinical trial, and 36.5% stated that they would be willing to participate. In multivariate models, blacks and Hispanics were equally likely as whites to be willing to participate in cancer trials, but Hispanics were less likely to have participated, and this was especially more likely in non-English-speaking Hispanics compared with English-speaking Hispanics. Notable barriers across race/ethnicity were mistrust and lack of knowledge of clinical trials. Limitations. Cross-sectional design limits cause-and-effect conclusions. CONCLUSIONS: . There are racial differences in participation rates but not in willingness to participate. We hypothesize that willingness to participate is not very high because people are uninformed about participating, particularly in non-English-speaking Hispanics. Barriers and facilitators to participation vary by race. Improved understanding of cultural differences that can be addressed by physicians may restore faith, comprehension, and acceptability of clinical trials by all patients.
Authors: Sandra E Brooks; Randy L Carter; Steven C Plaxe; Karen M Basen-Engquist; Michael Rodriguez; James Kauderer; Joan L Walker; Tashanna K N Myers; Janet G Drake; Laura J Havrilesky; Linda Van Le; Lisa M Landrum; Carol L Brown Journal: Gynecol Oncol Date: 2015-04-30 Impact factor: 5.482
Authors: Samantha Torres; Erika E de la Riva; Laura S Tom; Marla L Clayman; Chirisse Taylor; Xinqi Dong; Melissa A Simon Journal: J Cancer Educ Date: 2015-12 Impact factor: 2.037
Authors: Grace C Hillyer; Melissa Beauchemin; Dawn L Hershman; Moshe Kelsen; Frances L Brogan; Rossy Sandoval; Karen M Schmitt; Andria Reyes; Mary Beth Terry; Andrew B Lassman; Gary K Schwartz Journal: Clin Trials Date: 2020-02-03 Impact factor: 2.486
Authors: Christopher A Harle; Elizabeth H Golembiewski; Kiarash P Rahmanian; Janice L Krieger; Dorothy Hagmajer; Arch G Mainous; Ray E Moseley Journal: J Am Med Inform Assoc Date: 2018-03-01 Impact factor: 4.497
Authors: Jordan M Neil; Aisling Gough; Frank Kee; Thomas J George; Jeffrey Pufahl; Janice L Krieger Journal: J Cancer Educ Date: 2019-08 Impact factor: 2.037