Literature DB >> 23894727

Reasons for Staying as a Participant in the Environmental Determinants of Diabetes in the Young (TEDDY) Longitudinal Study.

Barbro Lernmark1, Kristian Lynch, Lori Ballard, Judith Baxter, Roswith Roth, Tuula Simell, Suzanne Bennett Johnson.   

Abstract

OBJECTIVE: To assess parents' opinions about their participation in the longitudinal, multicenter study - The Environmental Determinants of Diabetes in the Young (TEDDY) consortium.
METHODS: A survey was given to parents who had been in the study for ≥ 1 year. Parents rated the importance of different reasons for staying in TEDDY and how well different study components were working. Parents were also asked if they had suggestions for making TEDDY better and if they ever had thought of leaving TEDDY and if so, why.
RESULTS: Out of the 3336 eligible families, 2000 completed the survey (59.1%); most (77.6%) were mothers. Survey completion was more common in European than US TEDDY sites and was associated with greater maternal education, more accurate perceptions about their child's risk of type 1 diabetes, longer participation in TEDDY and excellent attendance at TEDDY visits. "Having someone watching the child for development of T1DM" was most important reason given for staying in the study; other important reasons included "Helping science discover causes of diabetes" and "Getting child's antibody results". Most parents were very satisfied with the different components of TEDDY and had not thought of leaving the study. A minority (24%) of parents acknowledged some thoughts of leaving TEDDY and cited the blood draws, being too busy/not having enough time, the demanding protocol, and food diaries as their reasons for considering leaving.
CONCLUSIONS: The study highlights factors important for successful implementation of demanding, longitudinal protocols. Friendly, devoted, skilled and knowledgeable staff with continuity makes the family comfortable. Keeping parents involved and informed on study progress is essential as is making procedures as smooth and painless as possible. Although the study is international the survey results were convergent across countries suggesting that the results have relevance to other similar studies to retain study participants.

Entities:  

Keywords:  Clinical observational study; Diabetes mellitus; Natural history; Participation; Type 1 Diabetes

Year:  2012        PMID: 23894727      PMCID: PMC3723141          DOI: 10.4172/2167-0870.1000114

Source DB:  PubMed          Journal:  J Clin Trials        ISSN: 2167-0870


  9 in total

1.  Methods used to maintain a high level of participant involvement in a clinical trial.

Authors:  M E Hellard; M I Sinclair; A B Forbes; C K Fairley
Journal:  J Epidemiol Community Health       Date:  2001-05       Impact factor: 3.710

2.  Reasons for high retention in pediatric clinical trials: comparison of participant and staff responses in the Correction of Myopia Evaluation Trial.

Authors:  Lynette Dias; Elinor Schoenfeld; Jennifer Thomas; Catherine Baldwin; Jennifer McLeod; Justin Smith; Robert Owens; Leslie Hyman
Journal:  Clin Trials       Date:  2005       Impact factor: 2.486

3.  Why patients continue to participate in clinical research.

Authors:  David Wendler; Benjamin Krohmal; Ezekiel J Emanuel; Christine Grady
Journal:  Arch Intern Med       Date:  2008-06-23

4.  The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design.

Authors: 
Journal:  Pediatr Diabetes       Date:  2007-10       Impact factor: 4.866

5.  Participant and parent experiences in the parenteral insulin arm of the diabetes prevention trial for type 1 diabetes.

Authors:  Suzanne Bennett Johnson; Amy E Baughcum; Korey Hood; Lisa E Rafkin-Mervis; Desmond A Schatz
Journal:  Diabetes Care       Date:  2007-06-11       Impact factor: 19.112

6.  Practical matters, rather than lack of trust, motivate non-participation in a long-term cohort trial.

Authors:  Gert Helgesson; Mats G Hansson; Johnny Ludvigsson; Ulrica Swartling
Journal:  Pediatr Diabetes       Date:  2009-02-27       Impact factor: 4.866

7.  Enrollment experiences in a pediatric longitudinal observational study: The Environmental Determinants of Diabetes in the Young (TEDDY) study.

Authors:  Barbro Lernmark; Suzanne Bennett Johnson; Kendra Vehik; Laura Smith; Lori Ballard; Judy Baxter; Wendy McLeod; Roswith Roth; Tuula Simell
Journal:  Contemp Clin Trials       Date:  2011-03-17       Impact factor: 2.261

8.  The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants.

Authors:  William A Hagopian; Henry Erlich; Ake Lernmark; Marian Rewers; Anette G Ziegler; Olli Simell; Beena Akolkar; Robert Vogt; Alan Blair; Jorma Ilonen; Jeffrey Krischer; JinXiong She
Journal:  Pediatr Diabetes       Date:  2011-05-12       Impact factor: 3.409

9.  The Environmental Determinants of Diabetes in the Young (TEDDY) study: predictors of early study withdrawal among participants with no family history of type 1 diabetes.

Authors:  Suzanne Bennett Johnson; Hye-Seung Lee; Judy Baxter; Barbro Lernmark; Roswith Roth; Tuula Simell
Journal:  Pediatr Diabetes       Date:  2010-10-28       Impact factor: 3.409

  9 in total
  5 in total

1.  Comparison of a French pediatric type 1 diabetes cohort's responders and non-responders to an environmental questionnaire.

Authors:  Sophie Le Fur; Pierre Bougnères; Alain-Jacques Valleron
Journal:  BMC Public Health       Date:  2014-12-03       Impact factor: 3.295

2.  Is staff consistency important to parents' satisfaction in a longitudinal study of children at risk for type 1 diabetes: the TEDDY study.

Authors:  Jessica Melin; Kristian F Lynch; Markus Lundgren; Carin Andrén Aronsson; Helena Elding Larsson; Suzanne Bennett Johnson
Journal:  BMC Endocr Disord       Date:  2022-01-10       Impact factor: 3.263

3.  Parental Estimation of Their Child's Increased Type 1 Diabetes Risk During the First 2 Years of Participation in an International Observational Study: Results From the TEDDY study.

Authors:  Ulrica Swartling; Kristian Lynch; Laura Smith; Suzanne Bennett Johnson
Journal:  J Empir Res Hum Res Ethics       Date:  2016-05-30       Impact factor: 1.978

4.  Participant Experiences in the Environmental Determinants of Diabetes in the Young Study: Common Reasons for Withdrawing.

Authors:  Barbro Lernmark; Kristian Lynch; Judith Baxter; Roswith Roth; Tuula Simell; Laura Smith; Ulrica Swartling; Suzanne Bennett Johnson
Journal:  J Diabetes Res       Date:  2015-11-22       Impact factor: 4.061

Review 5.  The Environmental Determinants of Diabetes in the Young (TEDDY) Study: 2018 Update.

Authors:  Marian Rewers; Heikki Hyöty; Åke Lernmark; William Hagopian; Jin-Xiong She; Desmond Schatz; Anette-G Ziegler; Jorma Toppari; Beena Akolkar; Jeffrey Krischer
Journal:  Curr Diab Rep       Date:  2018-10-23       Impact factor: 5.430

  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.