Marian Rewers1, Heikki Hyöty2,3, Åke Lernmark4, William Hagopian5, Jin-Xiong She6, Desmond Schatz7, Anette-G Ziegler8, Jorma Toppari9, Beena Akolkar10,11, Jeffrey Krischer12. 1. Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, 1775 Aurora Ct, Aurora, CO, 80045, USA. marian.rewers@ucdenver.edu. 2. Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland. 3. Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland. 4. Department of Clinical Sciences, Lund University/CRC, Skane University, Malmö, Sweden. 5. Pacific Northwest Research Institute, Seattle, WA, USA. 6. Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA. 7. University of Florida, Gainesville, FL, USA. 8. Forschergruppe Diabetes e.V. and Institute of Diabetes Research, Helmholtz Zentrum, Munich, Germany. 9. Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland. 10. Department of Pediatrics, Turku University Hospital, Turku, Finland. 11. National Institutes of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. 12. Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Abstract
PURPOSE OF REVIEW: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. RECENT FINDINGS: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed "omics" studies will provide novel information on the pathogenesis of T1D.
PURPOSE OF REVIEW: The environmental triggers of islet autoimmunity leading to type 1 diabetes (T1D) need to be elucidated to inform primary prevention. The Environmental Determinants of Diabetes in the Young (TEDDY) Study follows from birth 8676 children with T1D risk HLA-DR-DQ genotypes in the USA, Finland, Germany, and Sweden. Most study participants (89%) have no first-degree relative with T1D. The primary outcomes include the appearance of one or more persistent islet autoantibodies (islet autoimmunity, IA) and clinical T1D. RECENT FINDINGS: As of February 28, 2018, 769 children had developed IA and 310 have progressed to T1D. Secondary outcomes include celiac disease and autoimmune thyroid disease. While the follow-up continues, TEDDY has already evaluated a number of candidate environmental triggers, including infections, probiotics, micronutrient, and microbiome. TEDDY results suggest that there are multiple pathways leading to the destruction of pancreatic beta-cells. Ongoing measurements of further specific exposures, gene variants, and gene-environment interactions and detailed "omics" studies will provide novel information on the pathogenesis of T1D.
Authors: Andreas Beyerlein; Xiang Liu; Ulla M Uusitalo; Minna Harsunen; Jill M Norris; Kristina Foterek; Suvi M Virtanen; Marian J Rewers; Jin-Xiong She; Olli Simell; Åke Lernmark; William Hagopian; Beena Akolkar; Anette-G Ziegler; Jeffrey P Krischer; Sandra Hummel Journal: Am J Clin Nutr Date: 2015-07-08 Impact factor: 7.045
Authors: Kaisa M Kemppainen; Kristian F Lynch; Edwin Liu; Maria Lönnrot; Ville Simell; Thomas Briese; Sibylle Koletzko; William Hagopian; Marian Rewers; Jin-Xiong She; Olli Simell; Jorma Toppari; Anette-G Ziegler; Beena Akolkar; Jeffrey P Krischer; Åke Lernmark; Heikki Hyöty; Eric W Triplett; Daniel Agardh Journal: Clin Gastroenterol Hepatol Date: 2016-11-10 Impact factor: 11.382
Authors: F Salami; M Abels; H Hyöty; F Vaziri-Sani; Ca Aronsson; K Vehik; A Delli; Wa Hagopian; M Rewers; Ag Ziegler; O Simell; B Akolkar; J Krischer; J She; A Lernmark Journal: Int J Probiotics Prebiotics Date: 2012-08
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Authors: Angela M Gutierrez; Erin Molly Frazar; Maria Victoria X Klaus; Pranto Paul; J Zach Hilt Journal: Adv Healthc Mater Date: 2021-12-11 Impact factor: 9.933
Authors: Giulia Frazzei; Ronald F van Vollenhoven; Brigit A de Jong; Sarah E Siegelaar; Dirkjan van Schaardenburg Journal: Front Immunol Date: 2022-06-30 Impact factor: 8.786
Authors: Jean M Lawrence; Jasmin Divers; Scott Isom; Sharon Saydah; Giuseppina Imperatore; Catherine Pihoker; Santica M Marcovina; Elizabeth J Mayer-Davis; Richard F Hamman; Lawrence Dolan; Dana Dabelea; David J Pettitt; Angela D Liese Journal: JAMA Date: 2021-08-24 Impact factor: 157.335