Pin-Liang Chen1, Chih-Wen Yang, Yi-Kuan Tseng, Wei-Zen Sun, Jane-Ling Wang, Shuu-Jiun Wang, Yen-Jen Oyang, Jong-Ling Fuh. 1. Pin-Liang Chen, MS, Department of Computer Science and Information Engineering, National Taiwan University, Taipei; Chih-Wen Yang, MD, Department of Neurology, Taipei Veterans General Hospital, Su-Ao and Yuanshan Branch, and National Yang-Ming University School of Medicine, Taipei; Yi-Kuan Tseng, PhD, Graduate Institute of Statistics, National Central University, Jhongli; Wei-Zen Sun, MD, PhD, Department of Anaesthesiology, National Taiwan University Hospital, Taipei, Taiwan; Jane-Ling Wang, PhD, Department of Statistics, University of California, Davis, California, USA; Shuu-Jiun Wang, MD, National Yang-Ming University School of Medicine, and Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei; Yen-Jen Oyang, PhD, Department of Computer Science and Information Engineering, National Taiwan University, and Graduate Institutes of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei; Jong-Ling Fuh, MD, Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, and National Yang-Ming University School of Medicine, Taipei, Taiwan.
Abstract
BACKGROUND: The potential relationship between anaesthesia, surgery and onset of dementia remains elusive. AIMS: To determine whether the risk of dementia increases after surgery with anaesthesia, and to evaluate possible associations among age, mode of anaesthesia, type of surgery and risk of dementia. METHOD: The study cohort comprised patients aged 50 years and older who were anaesthetised for the first time since 1995 between 1 January 2004 and 31 December 2007, and a control group of randomly selected patients matched for age and gender. Patients were followed until 31 December 2010 to identify the emergence of dementia. RESULTS: Relative to the control group, patients who underwent anaesthesia and surgery exhibited an increased risk of dementia (hazard ratio = 1.99) and a reduced mean interval to dementia diagnosis. The risk of dementia increased in patients who received intravenous or intramuscular anaesthesia, regional anaesthesia and general anaesthesia. CONCLUSIONS: The results of our nationwide, population-based study suggest that patients who undergo anaesthesia and surgery may be at increased risk of dementia.
BACKGROUND: The potential relationship between anaesthesia, surgery and onset of dementia remains elusive. AIMS: To determine whether the risk of dementia increases after surgery with anaesthesia, and to evaluate possible associations among age, mode of anaesthesia, type of surgery and risk of dementia. METHOD: The study cohort comprised patients aged 50 years and older who were anaesthetised for the first time since 1995 between 1 January 2004 and 31 December 2007, and a control group of randomly selected patients matched for age and gender. Patients were followed until 31 December 2010 to identify the emergence of dementia. RESULTS: Relative to the control group, patients who underwent anaesthesia and surgery exhibited an increased risk of dementia (hazard ratio = 1.99) and a reduced mean interval to dementia diagnosis. The risk of dementia increased in patients who received intravenous or intramuscular anaesthesia, regional anaesthesia and general anaesthesia. CONCLUSIONS: The results of our nationwide, population-based study suggest that patients who undergo anaesthesia and surgery may be at increased risk of dementia.
Authors: H Abildstrom; L S Rasmussen; P Rentowl; C D Hanning; H Rasmussen; P A Kristensen; J T Moller Journal: Acta Anaesthesiol Scand Date: 2000-11 Impact factor: 2.105
Authors: Roderic G Eckenhoff; Jonas S Johansson; Huafeng Wei; Anna Carnini; Baobin Kang; Wenlin Wei; Ravindernath Pidikiti; Jason M Keller; Maryellen F Eckenhoff Journal: Anesthesiology Date: 2004-09 Impact factor: 7.892
Authors: Carsten D Fütterer; Martin H Maurer; Anne Schmitt; Robert E Feldmann; Wolfgang Kuschinsky; Klaus F Waschke Journal: Anesthesiology Date: 2004-02 Impact factor: 7.892
Authors: M Gasparini; N Vanacore; C Schiaffini; L Brusa; M Panella; G Talarico; G Bruno; G Meco; G L Lenzi Journal: Neurol Sci Date: 2002-04 Impact factor: 3.307
Authors: Jane A Driver; Alexa Beiser; Rhoda Au; Bernard E Kreger; Greta Lee Splansky; Tobias Kurth; Douglas P Kiel; Kun Ping Lu; Sudha Seshadri; Phillip A Wolf Journal: BMJ Date: 2012-03-12
Authors: Miles Berger; Jacob W Nadler; Jeffrey Browndyke; Niccolo Terrando; Vikram Ponnusamy; Harvey Jay Cohen; Heather E Whitson; Joseph P Mathew Journal: Anesthesiol Clin Date: 2015-07-16
Authors: Bryan D James; Robert S Wilson; Ana W Capuano; Patricia A Boyle; Raj C Shah; Melissa Lamar; E Wesley Ely; David A Bennett; Julie A Schneider Journal: Neurology Date: 2019-01-11 Impact factor: 9.910
Authors: P J Schulte; R O Roberts; D S Knopman; R C Petersen; A C Hanson; D R Schroeder; T N Weingarten; D P Martin; D O Warner; J Sprung Journal: Br J Anaesth Date: 2018-06-27 Impact factor: 9.166
Authors: Katie J Schenning; Charles F Murchison; Nora C Mattek; Lisa C Silbert; Jeffrey A Kaye; Joseph F Quinn Journal: Alzheimers Dement Date: 2015-11-25 Impact factor: 21.566
Authors: Juraj Sprung; Phillip J Schulte; David S Knopman; Michelle M Mielke; Ronald C Petersen; Toby N Weingarten; David P Martin; Andrew C Hanson; Darrell R Schroeder; David O Warner Journal: Alzheimers Dement Date: 2019-09-05 Impact factor: 21.566