OBJECTIVE: To investigate the role of interleukin 6 (IL6) and IL16 single nucleotide polymorphisms (SNPs) in coronary artery disease (CAD) risk in a Chinese population. METHODS: Patients with CAD and healthy control subjects were recruited. IL6 (rs1800795 and rs1800796) and IL16 (rs8034928, rs3848180, rs4577037, rs1131445, rs4778889 and rs11556218) genotyping was performed on the MassARRAY® platform (Sequenom®, San Diego, CA, USA). RESULTS: Frequencies of rs8034928 variant C allele and rs11556218 variant T allele were higher in patients with CAD (n = 326) than controls (n = 341). The rs8034928 C/C genotype (odds ratio [OR] 2.03; 95% confidence intervals [CI] 1.16, 3.62) and C allele (OR 1.97; 95%CI 1.15, 3.45) were associated with increased risk of CAD compared with wild type. Similarly, the rs11556218 T/T genotype (OR 2.44; 95%CI 1.15, 5.44) and T allele (OR 2.37; 95%CI 1.13, 5.24) were associated with increased CAD risk compared with wild type. CONCLUSION: The SNPs rs8034928 and rs11556218 are associated with CAD risk in the Chinese population, and may be useful predictive markers for CAD susceptibility.
OBJECTIVE: To investigate the role of interleukin 6 (IL6) and IL16 single nucleotide polymorphisms (SNPs) in coronary artery disease (CAD) risk in a Chinese population. METHODS:Patients with CAD and healthy control subjects were recruited. IL6 (rs1800795 and rs1800796) and IL16 (rs8034928, rs3848180, rs4577037, rs1131445, rs4778889 and rs11556218) genotyping was performed on the MassARRAY® platform (Sequenom®, San Diego, CA, USA). RESULTS: Frequencies of rs8034928 variant C allele and rs11556218 variant T allele were higher in patients with CAD (n = 326) than controls (n = 341). The rs8034928 C/C genotype (odds ratio [OR] 2.03; 95% confidence intervals [CI] 1.16, 3.62) and C allele (OR 1.97; 95%CI 1.15, 3.45) were associated with increased risk of CAD compared with wild type. Similarly, the rs11556218 T/T genotype (OR 2.44; 95%CI 1.15, 5.44) and T allele (OR 2.37; 95%CI 1.13, 5.24) were associated with increased CAD risk compared with wild type. CONCLUSION: The SNPs rs8034928 and rs11556218 are associated with CAD risk in the Chinese population, and may be useful predictive markers for CAD susceptibility.
Authors: Nasimudeen R Jabir; Chelapram K Firoz; Mohammad A Kamal; Ghazi A Damanhouri; Mohammed Nabil Alama; Anas S Alzahrani; Hussein A Almehdar; Shams Tabrez Journal: J Clin Lab Anal Date: 2016-11-09 Impact factor: 2.352
Authors: Rachid Abaji; Vincent Gagné; Chang Jiang Xu; Jean-François Spinella; Francesco Ceppi; Caroline Laverdière; Jean-Marie Leclerc; Stephen E Sallan; Donna Neuberg; Jeffery L Kutok; Lewis B Silverman; Daniel Sinnett; Maja Krajinovic Journal: Oncotarget Date: 2017-07-04
Authors: Michail Matalliotakis; Maria I Zervou; Elias Eliopoulos; Charoula Matalliotaki; Nilufer Rahmioglu; Ioannis Kalogiannidis; Krina Zondervan; Demetrios A Spandidos; Ioannis Matalliotakis; George N Goulielmos Journal: Int J Mol Med Date: 2018-01-09 Impact factor: 4.101