Literature DB >> 23870141

The cGAS-STING pathway for DNA sensing.

T Sam Xiao1, Katherine A Fitzgerald.   

Abstract

The nucleotidyl transferase cGAS, its second-messenger product cGAMP, and the cGAMP sensor STING form the basic mechanism of DNA sensing in the cytoplasm of mammalian cells. Several new reports now uncover key structural features associated with DNA recognition by cGAS and the catalytic mechanisms of cGAMP generation. Concurrent studies also reveal unique phosphodiester linkages in endogenous cGAMP that distinguish it from microbial cGAMP and other cyclic dinucleotides. Together, these studies provide a new perspective on DNA recognition in the innate immune system.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23870141      PMCID： PMC3782533          DOI： 10.1016/j.molcel.2013.07.004

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  29 in total

1.  Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP.

Authors:  Guijun Shang; Deyu Zhu; Ning Li; Junbing Zhang; Chunyuan Zhu; Defen Lu; Cuilan Liu; Qian Yu; Yanyu Zhao; Sujuan Xu; Lichuan Gu
Journal:  Nat Struct Mol Biol       Date:  2012-06-24       Impact factor: 15.369

2.  The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation.

Authors:  Bo Zhong; Yan Yang; Shu Li; Yan-Yi Wang; Ying Li; Feici Diao; Caoqi Lei; Xiao He; Lu Zhang; Po Tien; Hong-Bing Shu
Journal:  Immunity       Date:  2008-09-25       Impact factor: 31.745

3.  pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

Authors:  I M Kerr; R E Brown
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

4.  Interferon-induced enzymatic activities and their role in the antriviral state.

Authors:  C Baglioni
Journal:  Cell       Date:  1979-06       Impact factor: 41.582

5.  Cyclic di-GMP sensing via the innate immune signaling protein STING.

Authors:  Qian Yin; Yuan Tian; Venkataraman Kabaleeswaran; Xiaomo Jiang; Daqi Tu; Michael J Eck; Zhijian J Chen; Hao Wu
Journal:  Mol Cell       Date:  2012-06-14       Impact factor: 17.970

6.  Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Authors:  Lijun Sun; Jiaxi Wu; Fenghe Du; Xiang Chen; Zhijian J Chen
Journal:  Science       Date:  2012-12-20       Impact factor: 47.728

7.  The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

Authors:  Elie J Diner; Dara L Burdette; Stephen C Wilson; Kathryn M Monroe; Colleen A Kellenberger; Mamoru Hyodo; Yoshihiro Hayakawa; Ming C Hammond; Russell E Vance
Journal:  Cell Rep       Date:  2013-05-23       Impact factor: 9.423

8.  Species-specific detection of the antiviral small-molecule compound CMA by STING.

Authors:  Taner Cavlar; Tobias Deimling; Andrea Ablasser; Karl-Peter Hopfner; Veit Hornung
Journal:  EMBO J       Date:  2013-04-19       Impact factor: 11.598

9.  The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response.

Authors:  Kislay Parvatiyar; Zhiqiang Zhang; Rosane M Teles; Songying Ouyang; Yan Jiang; Shankar S Iyer; Shivam A Zaver; Mirjam Schenk; Shang Zeng; Wenwan Zhong; Zhi-Jie Liu; Robert L Modlin; Yong-jun Liu; Genhong Cheng
Journal:  Nat Immunol       Date:  2012-11-11       Impact factor: 25.606

10.  Structural mechanism of cytosolic DNA sensing by cGAS.

Authors:  Filiz Civril; Tobias Deimling; Carina C de Oliveira Mann; Andrea Ablasser; Manuela Moldt; Gregor Witte; Veit Hornung; Karl-Peter Hopfner
Journal:  Nature       Date:  2013-05-30       Impact factor: 49.962
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  70 in total

1.  Identification of novel gene signatures in patients with atopic dermatitis complicated by eczema herpeticum.

Authors:  Lianghua Bin; Michael G Edwards; Ryan Heiser; Joanne E Streib; Brittany Richers; Clifton F Hall; Donald Y M Leung
Journal:  J Allergy Clin Immunol       Date:  2014-08-23       Impact factor: 10.793

Review 2.  Multifaceted roles of TRIM38 in innate immune and inflammatory responses.

Authors:  Ming-Ming Hu; Hong-Bing Shu
Journal:  Cell Mol Immunol       Date:  2017-02-13       Impact factor: 11.530

Review 3.  Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease.

Authors:  Evelyn A Kurt-Jones; Megan H Orzalli; David M Knipe
Journal:  Adv Anat Embryol Cell Biol       Date:  2017       Impact factor: 1.231

Review 4.  Scaling of immune responses against intracellular bacterial infection.

Authors:  Zeinab Abdullah; Percy A Knolle
Journal:  EMBO J       Date:  2014-09-15       Impact factor: 11.598

Review 5.  Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors.

Authors:  Surya Pandey; Taro Kawai; Shizuo Akira
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-10-09       Impact factor: 10.005

6.  DNA degradation and its defects.

Authors:  Kohki Kawane; Kou Motani; Shigekazu Nagata
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-06-02       Impact factor: 10.005

Review 7.  Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA.

Authors:  Henrique Lemos; Lei Huang; Tracy L McGaha; Andrew L Mellor
Journal:  Eur J Immunol       Date:  2014-08-25       Impact factor: 5.532

Review 8.  Utilization of different anti-viral mechanisms by mammalian embryonic stem cells and differentiated cells.

Authors:  Yan-Lin Guo
Journal:  Immunol Cell Biol       Date:  2016-08-03       Impact factor: 5.126

9.  cGAS/STING Pathway Activation Contributes to Delayed Neurodegeneration in Neonatal Hypoxia-Ischemia Rat Model: Possible Involvement of LINE-1.

Authors:  Marcin Gamdzyk; Desislava Met Doycheva; Camila Araujo; Umut Ocak; Yujie Luo; Jiping Tang; John H Zhang
Journal:  Mol Neurobiol       Date:  2020-04-06       Impact factor: 5.590

Review 10.  Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation.

Authors:  Shruti Sharma; Katharine A Fitzgerald; Michael P Cancro; Ann Marshak-Rothstein
Journal:  J Immunol       Date:  2015-10-15       Impact factor: 5.422
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