Literature DB >> 24890510

DNA degradation and its defects.

Kohki Kawane1, Kou Motani1, Shigekazu Nagata2.   

Abstract

DNA is one of the most essential molecules in organisms, containing all the information necessary for organisms to live. It replicates and provides a mechanism for heredity and evolution. Various events cause the degradation of DNA into nucleotides. DNA also has a darker side that has only recently been recognized; DNA that is not properly degraded causes various diseases. In this review, we discuss four deoxyribonucleases that function in the nucleus, cytosol, and lysosomes, and how undigested DNA causes such diseases as cancer, cataract, and autoinflammation. Studies on the biochemical and physiological functions of deoxyribonucleases should continue to increase our understanding of cellular functions and human diseases.
Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2014        PMID： 24890510      PMCID： PMC4031964          DOI： 10.1101/cshperspect.a016394

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Biol        ISSN： 1943-0264            Impact factor:   10.005


  108 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-23       Impact factor: 11.205

2.  Interferons alpha/beta inhibit IL-7-induced proliferation of CD4- CD8- CD3- CD44+ CD25+ thymocytes, but do not inhibit that of CD4- CD8- CD3- CD44- CD25- thymocytes.

Authors:  D M Su; J Wang; Q Lin; M D Cooper; T Watanabe
Journal:  Immunology       Date:  1997-04       Impact factor: 7.397

3.  Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages.

Authors:  Kohki Kawane; Mayumi Ohtani; Keiko Miwa; Takuji Kizawa; Yoshiyuki Kanbara; Yoshichika Yoshioka; Hideki Yoshikawa; Shigekazu Nagata
Journal:  Nature       Date:  2006-10-26       Impact factor: 49.962

4.  Identification of a factor that links apoptotic cells to phagocytes.

Authors:  Rikinari Hanayama; Masato Tanaka; Keiko Miwa; Azusa Shinohara; Akihiro Iwamatsu; Shigekazu Nagata
Journal:  Nature       Date:  2002-05-09       Impact factor: 49.962

5.  Phagocytosis and clearance of apoptotic cells is mediated by MER.

Authors:  R S Scott; E J McMahon; S M Pop; E A Reap; R Caricchio; P L Cohen; H S Earp; G K Matsushima
Journal:  Nature       Date:  2001-05-10       Impact factor: 49.962

Review 6.  The many roles of FAS receptor signaling in the immune system.

Authors:  Andreas Strasser; Philipp J Jost; Shigekazu Nagata
Journal:  Immunity       Date:  2009-02-20       Impact factor: 31.745

7.  The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses.

Authors:  Vijay A K Rathinam; Zhaozhao Jiang; Stephen N Waggoner; Shruti Sharma; Leah E Cole; Lisa Waggoner; Sivapriya Kailasan Vanaja; Brian G Monks; Sandhya Ganesan; Eicke Latz; Veit Hornung; Stefanie N Vogel; Eva Szomolanyi-Tsuda; Katherine A Fitzgerald
Journal:  Nat Immunol       Date:  2010-03-28       Impact factor: 25.606

8.  Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45.

Authors:  J Zhang; X Liu; D C Scherer; L van Kaer; X Wang; M Xu
Journal:  Proc Natl Acad Sci U S A       Date:  1998-10-13       Impact factor: 11.205

9.  Trex1 prevents cell-intrinsic initiation of autoimmunity.

Authors:  Daniel B Stetson; Joan S Ko; Thierry Heidmann; Ruslan Medzhitov
Journal:  Cell       Date:  2008-08-22       Impact factor: 41.582

10.  Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

Authors:  J Keffer; L Probert; H Cazlaris; S Georgopoulos; E Kaslaris; D Kioussis; G Kollias
Journal:  EMBO J       Date:  1991-12       Impact factor: 11.598
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  27 in total

Review 1.  International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease.

Authors:  Clare E Bryant; Selinda Orr; Brian Ferguson; Martyn F Symmons; Joseph P Boyle; Tom P Monie
Journal:  Pharmacol Rev       Date:  2015       Impact factor: 25.468

2.  Nuclear degradation dynamics in a nonapoptotic programmed cell death.

Authors:  Alla Yalonetskaya; Albert A Mondragon; Zackary J Hintze; Susan Holmes; Kimberly McCall
Journal:  Cell Death Differ       Date:  2019-07-08       Impact factor: 15.828

Review 3.  Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease.

Authors:  Holly Anderton; Ian P Wicks; John Silke
Journal:  Nat Rev Rheumatol       Date:  2020-07-08       Impact factor: 20.543

Review 4.  An Update on Autoinflammatory Diseases: Interferonopathies.

Authors:  Sophia Davidson; Annemarie Steiner; Cassandra R Harapas; Seth L Masters
Journal:  Curr Rheumatol Rep       Date:  2018-05-30       Impact factor: 4.592

5.  Autophagy in healthy aging and disease.

Authors:  Yahyah Aman; Tomas Schmauck-Medina; Malene Hansen; Richard I Morimoto; Anna Katharina Simon; Ivana Bjedov; Konstantinos Palikaras; Anne Simonsen; Terje Johansen; Nektarios Tavernarakis; David C Rubinsztein; Linda Partridge; Guido Kroemer; John Labbadia; Evandro F Fang
Journal:  Nat Aging       Date:  2021-08-12

Review 6.  Role of AIM2 inflammasome in inflammatory diseases, cancer and infection.

Authors:  Bhesh Raj Sharma; Rajendra Karki; Thirumala-Devi Kanneganti
Journal:  Eur J Immunol       Date:  2019-08-14       Impact factor: 5.532

7.  Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress.

Authors:  Alicia K Byrd; Boris L Zybailov; Leena Maddukuri; Jun Gao; John C Marecki; Mihir Jaiswal; Matthew R Bell; Wezley C Griffin; Megan R Reed; Shubeena Chib; Samuel G Mackintosh; Angus M MacNicol; Giulia Baldini; Robert L Eoff; Kevin D Raney
Journal:  J Biol Chem       Date:  2016-07-01       Impact factor: 5.157

8.  Activation of stimulator of interferon genes (STING) induces ADAM17-mediated shedding of the immune semaphorin SEMA4D.

Authors:  Kou Motani; Hidetaka Kosako
Journal:  J Biol Chem       Date:  2018-04-04       Impact factor: 5.157

Review 9.  Traumatic Brain Injury: Ultrastructural Features in Neuronal Ferroptosis, Glial Cell Activation and Polarization, and Blood-Brain Barrier Breakdown.

Authors:  Delong Qin; Junmin Wang; Anh Le; Tom J Wang; Xuemei Chen; Jian Wang
Journal:  Cells       Date:  2021-04-24       Impact factor: 6.600

Review 10.  The cGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease.

Authors:  Ruihua Ma; Tatiana P Ortiz Serrano; Jennifer Davis; Andrew D Prigge; Karen M Ridge
Journal:  FASEB J       Date:  2020-08-28       Impact factor: 5.191
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