BACKGROUND AND PURPOSE: Regular physical activity (PA) is an important recommendation for stroke prevention. We compared the associations of self-reported PA with incident stroke in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. METHODS: REGARDS recruited 30 239 US blacks (42%) and whites, aged ≥45 years with follow-up every 6 months for stroke events. Excluding those with prior stroke, analysis involved 27 348 participants who reported their frequency of moderate to vigorous intensity PA at baseline according to 3 categories: none (physical inactivity), 1 to 3×, and ≥4× per week. Stroke and transient ischemic attack cases were identified during an average of 5.7 years of follow-up. Cox proportional hazards models were constructed to examine whether self-reported PA was associated with risk of incident stroke. RESULTS: Physical inactivity was reported by 33% of participants and was associated with a hazard ratio of 1.20 (95% confidence intervals, 1.02-1.42; P=0.035). Adjustment for demographic and socioeconomic factors did not affect hazard ratio, but further adjustment for traditional stroke risk factors (diabetes mellitus, hypertension, body mass index, alcohol use, and smoking) partially attenuated this risk (hazard ratio, 1.14 [0.95-1.37]; P=0.17). There was no significant association between PA frequency and risk of stroke by sex groups, although there was a trend toward increased risk for men reporting PA 0 to 3× a week compared with ≥4× a week. CONCLUSIONS: Self-reported low PA frequency is associated with increased risk of incident stroke. Any effect of PA is likely to be mediated through reducing traditional risk factors.
BACKGROUND AND PURPOSE: Regular physical activity (PA) is an important recommendation for stroke prevention. We compared the associations of self-reported PA with incident stroke in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. METHODS: REGARDS recruited 30 239 US blacks (42%) and whites, aged ≥45 years with follow-up every 6 months for stroke events. Excluding those with prior stroke, analysis involved 27 348 participants who reported their frequency of moderate to vigorous intensity PA at baseline according to 3 categories: none (physical inactivity), 1 to 3×, and ≥4× per week. Stroke and transient ischemic attack cases were identified during an average of 5.7 years of follow-up. Cox proportional hazards models were constructed to examine whether self-reported PA was associated with risk of incident stroke. RESULTS: Physical inactivity was reported by 33% of participants and was associated with a hazard ratio of 1.20 (95% confidence intervals, 1.02-1.42; P=0.035). Adjustment for demographic and socioeconomic factors did not affect hazard ratio, but further adjustment for traditional stroke risk factors (diabetes mellitus, hypertension, body mass index, alcohol use, and smoking) partially attenuated this risk (hazard ratio, 1.14 [0.95-1.37]; P=0.17). There was no significant association between PA frequency and risk of stroke by sex groups, although there was a trend toward increased risk for men reporting PA 0 to 3× a week compared with ≥4× a week. CONCLUSIONS: Self-reported low PA frequency is associated with increased risk of incident stroke. Any effect of PA is likely to be mediated through reducing traditional risk factors.
Authors: G C W Wendel-Vos; A J Schuit; E J M Feskens; H C Boshuizen; W M M Verschuren; W H M Saris; D Kromhout Journal: Int J Epidemiol Date: 2004-05-27 Impact factor: 7.196
Authors: Alan S Go; Dariush Mozaffarian; Véronique L Roger; Emelia J Benjamin; Jarett D Berry; William B Borden; Dawn M Bravata; Shifan Dai; Earl S Ford; Caroline S Fox; Sheila Franco; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Mark D Huffman; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; David Magid; Gregory M Marcus; Ariane Marelli; David B Matchar; Darren K McGuire; Emile R Mohler; Claudia S Moy; Michael E Mussolino; Graham Nichol; Nina P Paynter; Pamela J Schreiner; Paul D Sorlie; Joel Stein; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner Journal: Circulation Date: 2012-12-12 Impact factor: 29.690
Authors: R Rauramaa; J T Salonen; K Seppänen; R Salonen; J M Venäläinen; M Ihanainen; V Rissanen Journal: Circulation Date: 1986-11 Impact factor: 29.690
Authors: Alan S Go; Dariush Mozaffarian; Véronique L Roger; Emelia J Benjamin; Jarett D Berry; Michael J Blaha; Shifan Dai; Earl S Ford; Caroline S Fox; Sheila Franco; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Mark D Huffman; Suzanne E Judd; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; Rachel H Mackey; David J Magid; Gregory M Marcus; Ariane Marelli; David B Matchar; Darren K McGuire; Emile R Mohler; Claudia S Moy; Michael E Mussolino; Robert W Neumar; Graham Nichol; Dilip K Pandey; Nina P Paynter; Matthew J Reeves; Paul D Sorlie; Joel Stein; Amytis Towfighi; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner Journal: Circulation Date: 2013-12-18 Impact factor: 29.690
Authors: Emelia J Benjamin; Michael J Blaha; Stephanie E Chiuve; Mary Cushman; Sandeep R Das; Rajat Deo; Sarah D de Ferranti; James Floyd; Myriam Fornage; Cathleen Gillespie; Carmen R Isasi; Monik C Jiménez; Lori Chaffin Jordan; Suzanne E Judd; Daniel Lackland; Judith H Lichtman; Lynda Lisabeth; Simin Liu; Chris T Longenecker; Rachel H Mackey; Kunihiro Matsushita; Dariush Mozaffarian; Michael E Mussolino; Khurram Nasir; Robert W Neumar; Latha Palaniappan; Dilip K Pandey; Ravi R Thiagarajan; Mathew J Reeves; Matthew Ritchey; Carlos J Rodriguez; Gregory A Roth; Wayne D Rosamond; Comilla Sasson; Amytis Towfighi; Connie W Tsao; Melanie B Turner; Salim S Virani; Jenifer H Voeks; Joshua Z Willey; John T Wilkins; Jason Hy Wu; Heather M Alger; Sally S Wong; Paul Muntner Journal: Circulation Date: 2017-01-25 Impact factor: 29.690
Authors: Michelle N McDonnell; Susan L Hillier; Suzanne E Judd; Ya Yuan; Steven P Hooker; Virginia J Howard Journal: Prev Med Date: 2016-02-13 Impact factor: 4.018
Authors: Jalal Uddin; Gargya Malla; Andrea L Cherrington; Sha Zhu; Doyle M Cummings; Olivio J Clay; Todd M Brown; Loretta T Lee; Ruth W Kimokoti; Mary Cushman; Monika M Safford; April P Carson Journal: Prev Med Date: 2020-07-20 Impact factor: 4.018
Authors: Virginia J Howard; J David Rhodes; Aleena Mosher; Brent Hutto; Margaret S Stewart; Natalie Colabianchi; John E Vena; Steven N Blair; Steven P Hooker Journal: Med Sci Sports Exerc Date: 2015-07 Impact factor: 5.411
Authors: Mayowa Owolabi; Fred Sarfo; Virginia J Howard; Marguerite R Irvin; Mulugeta Gebregziabher; Rufus Akinyemi; Aleena Bennett; Kevin Armstrong; Hemant K Tiwari; Albert Akpalu; Kolawole W Wahab; Lukman Owolabi; Bimbo Fawale; Morenikeji Komolafe; Reginald Obiako; Philip Adebayo; Jennifer M Manly; Godwin Ogbole; Ezinne Melikam; Ruth Laryea; Raelle Saulson; Carolyn Jenkins; Donna K Arnett; Daniel T Lackland; Bruce Ovbiagele; George Howard Journal: Stroke Date: 2017-04-07 Impact factor: 7.914
Authors: Joshua Z Willey; Jenna Voutsinas; Ayesha Sherzai; Huiyan Ma; Leslie Bernstein; Mitchell S V Elkind; Ying K Cheung; Sophia S Wang Journal: Stroke Date: 2017-08-09 Impact factor: 7.914
Authors: Justin Xavier Moore; Stephen J Carter; Victoria Williams; Saira Khan; Marquita W Lewis-Thames; Keon Gilbert; George Howard Journal: Prev Med Date: 2020-01-16 Impact factor: 4.018