| Literature DB >> 26254053 |
Lisa M Wheatley1, Marshall Plaut2, Julie M Schwaninger2, Aleena Banerji3, Mariana Castells4, Fred D Finkelman5, Gerald J Gleich6, Emma Guttman-Yassky7, Simon A K Mallal8, Dean J Naisbitt9, David A Ostrov10, Elizabeth J Phillips11, Werner J Pichler12, Thomas A E Platts-Mills13, Jean-Claude Roujeau14, Lawrence B Schwartz15, Lauren A Trepanier16.
Abstract
Allergic reactions to drugs are a serious public health concern. In 2013, the Division of Allergy, Immunology, and Transplantation of the National Institute of Allergy and Infectious Diseases sponsored a workshop on drug allergy. International experts in the field of drug allergy with backgrounds in allergy, immunology, infectious diseases, dermatology, clinical pharmacology, and pharmacogenomics discussed the current state of drug allergy research. These experts were joined by representatives from several National Institutes of Health institutes and the US Food and Drug Administration. The participants identified important advances that make new research directions feasible and made suggestions for research priorities and for development of infrastructure to advance our knowledge of the mechanisms, diagnosis, management, and prevention of drug allergy. The workshop summary and recommendations are presented herein. Published by Elsevier Inc.Entities:
Keywords: Drug allergy; Stevens-Johnson syndrome; altered peptide repertoire hypothesis; desensitization; drug hypersensitivity; hapten hypothesis; pharmacogenomics; pharmacologic interaction with immune receptor hypothesis; toxic epidermal necrolysis
Mesh：
Substances：
Year: 2015 PMID： 26254053 PMCID： PMC4529958 DOI： 10.1016/j.jaci.2015.05.027
Source DB: PubMed Journal: J Allergy Clin Immunol ISSN： 0091-6749 Impact factor: 10.793