Literature DB >> 23861326

An isotopically tagged azobenzene-based cleavable linker for quantitative proteomics.

Yu Qian1, Julianne Martell, Nicholas J Pace, T Eric Ballard, Douglas S Johnson, Eranthie Weerapana.   

Abstract

Putting a number on it: Cleavable linkers are widely utilized in proteomics applications. In particular, the azobenzene-based linker cleaves under mild conditions that are mass-spectrometry-compatible. Here, we adapt this linker for quantitative proteomic applications by incorporating an isotopic label. These light- and heavy-tagged linkers enable the identification and quantitation of labeled peptides from multiple proteomes.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  azobenzene; cleavable linkers; heavy isotopes; mass spectrometry; quantitative proteomics

Mesh：

Substances：

Year:  2013        PMID： 23861326     DOI： 10.1002/cbic.201300396

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  28 in total

1.  Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins.

Authors:  Melissa M Budelier; Wayland W L Cheng; Lucie Bergdoll; Zi-Wei Chen; Jeff Abramson; Kathiresan Krishnan; Mingxing Qian; Douglas F Covey; James W Janetka; Alex S Evers
Journal:  Anal Chem       Date:  2017-02-09       Impact factor: 6.986

2.  Identifying Functional Cysteine Residues in the Mitochondria.

Authors:  Daniel W Bak; Mattia D Pizzagalli; Eranthie Weerapana
Journal:  ACS Chem Biol       Date:  2017-02-15       Impact factor: 5.100

Review 3.  From structure to redox: The diverse functional roles of disulfides and implications in disease.

Authors:  Tyler J Bechtel; Eranthie Weerapana
Journal:  Proteomics       Date:  2017-03       Impact factor: 3.984

Review 4.  Chemical Probes for Redox Signaling and Oxidative Stress.

Authors:  Masahiro Abo; Eranthie Weerapana
Journal:  Antioxid Redox Signal       Date:  2017-12-22       Impact factor: 8.401

5.  Global Cysteine-Reactivity Profiling during Impaired Insulin/IGF-1 Signaling in C. elegans Identifies Uncharacterized Mediators of Longevity.

Authors:  Julianne Martell; Yonghak Seo; Daniel W Bak; Samuel F Kingsley; Heidi A Tissenbaum; Eranthie Weerapana
Journal:  Cell Chem Biol       Date:  2016-08-04       Impact factor: 8.116

6.  Isotopically-Labeled Iodoacetamide-Alkyne Probes for Quantitative Cysteine-Reactivity Profiling.

Authors:  Masahiro Abo; Chun Li; Eranthie Weerapana
Journal:  Mol Pharm       Date:  2017-12-06       Impact factor: 4.939

7.  A cysteinyl-tRNA synthetase variant confers resistance against selenite toxicity and decreases selenocysteine misincorporation.

Authors:  Kyle S Hoffman; Oscar Vargas-Rodriguez; Daniel W Bak; Takahito Mukai; Laura K Woodward; Eranthie Weerapana; Dieter Söll; Noah M Reynolds
Journal:  J Biol Chem       Date:  2019-07-11       Impact factor: 5.157

8.  Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry.

Authors:  Susan E Hagen; Kun Liu; Yafei Jin; Lolita Piersimoni; Philip C Andrews; Hollis D Showalter
Journal:  Org Biomol Chem       Date:  2018-09-26       Impact factor: 3.876

9.  Optimization of Caged Electrophiles for Improved Monitoring of Cysteine Reactivity in Living Cells.

Authors:  Masahiro Abo; Daniel W Bak; Eranthie Weerapana
Journal:  Chembiochem       Date:  2016-12-05       Impact factor: 3.164

10.  A Quantitative Mass-Spectrometry Platform to Monitor Changes in Cysteine Reactivity.

Authors:  Yu Qian; Eranthie Weerapana
Journal:  Methods Mol Biol       Date:  2017
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