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Literature DB >> 29537042

Synthesis of CID-cleavable protein crosslinking agents containing quaternary amines for structural mass spectrometry.

Susan E Hagen¹, Kun Liu, Yafei Jin, Lolita Piersimoni, Philip C Andrews, Hollis D Showalter.

Abstract

Two novel cyclic quaternary amine crosslinking probes are synthesized for structural mass spectrometry of protein complexes in solution and for analysis of protein interactions in organellar and whole cell extracts. Each exhibits high aqueous solubility, excellent protein crosslinking efficiencies, low collision induced dissociation (CID) energy fragmentation efficiencies, high stoichiometries of reaction, increased charges of crosslinked peptide ions, and maintenance of overall surface charge balance of crosslinked proteins.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2018 PMID： 29537042 PMCID： PMC6138586 DOI： 10.1039/c8ob00329g

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

42 in total

1. Quaternary diamines as mass spectrometry cleavable crosslinkers for protein interactions.

Authors: Billy Clifford-Nunn; H D Hollis Showalter; Philip C Andrews
Journal: J Am Soc Mass Spectrom Date: 2011-12-01 Impact factor: 3.109

2. Chemical cross-linking and mass spectrometry as a low-resolution protein structure determination technique.

Authors: Pragya Singh; Alexandre Panchaud; David R Goodlett
Journal: Anal Chem Date: 2010-04-01 Impact factor: 6.986

Review 3. Cross-Linking Mass Spectrometry: An Emerging Technology for Interactomics and Structural Biology.

Authors: Clinton Yu; Lan Huang
Journal: Anal Chem Date: 2017-11-21 Impact factor: 6.986

4. Identification of cross-linked peptides after click-based enrichment using sequential collision-induced dissociation and electron transfer dissociation tandem mass spectrometry.

Authors: Saiful M Chowdhury; Xiuxia Du; Nikola Tolić; Si Wu; Ronald J Moore; M Uljana Mayer; Richard D Smith; Joshua N Adkins
Journal: Anal Chem Date: 2009-07-01 Impact factor: 6.986

5. Design of CID-cleavable protein cross-linkers: identical mass modifications for simpler sequence analysis.

Authors: Wynne V Kandur; Athit Kao; Danielle Vellucci; Lan Huang; Scott D Rychnovsky
Journal: Org Biomol Chem Date: 2015-10-14 Impact factor: 3.876

6. Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.

Authors: Brian C Raimundo; Johan D Oslob; Andrew C Braisted; Jennifer Hyde; Robert S McDowell; Mike Randal; Nathan D Waal; Jennifer Wilkinson; Chul H Yu; Michelle R Arkin
Journal: J Med Chem Date: 2004-06-03 Impact factor: 7.446

7. Antiproliferative and phenotype-transforming antitumor agents derived from cysteine.

Authors: Matthew P Glenn; Pia Kahnberg; Glen M Boyle; Karl A Hansford; Dhiraj Hans; Adam C Martyn; Peter G Parsons; David P Fairlie
Journal: J Med Chem Date: 2004-06-03 Impact factor: 7.446

8. Annexin A2/P11 interaction: new insights into annexin A2 tetramer structure by chemical crosslinking, high-resolution mass spectrometry, and computational modeling.

Authors: Daniela M Schulz; Stefan Kalkhof; Andreas Schmidt; Christian Ihling; Christoph Stingl; Karl Mechtler; Olaf Zschörnig; Andrea Sinz
Journal: Proteins Date: 2007-11-01

Review 2. Interfaces with Structure Dynamics of the Workhorses from Cells Revealed through Cross-Linking Mass Spectrometry (CLMS).

Authors: Umesh Kalathiya; Monikaben Padariya; Jakub Faktor; Etienne Coyaud; Javier A Alfaro; Robin Fahraeus; Ted R Hupp; David R Goodlett
Journal: Biomolecules Date: 2021-03-04

2 in total