Endoscopic management of benign biliary strictures.

The majority of recent studies of benign biliary strictures (BBSs) have reported on treatment of stenotic injuries following cholecystectomy, orthotopic liver transplantation, living donor liver transplantation, chronic pancreatitis, and different inflammatory conditions such as common bile-duct-related strictures. Information about previous surgical procedures is very important for making a BBS diagnosis. Diagnostic tools for indeterminate strictures have increased to include (1) highly specialized cytological techniques such as fluorescence in situ hybridization, (2) cholangioscopy, and (3) endoscopic ultrasound with fine needle aspiration (FNA) and intraductal ultrasound. Magnetic resonance cholangiopancreatography before endoscopic retrograde cholangiopancreatography (ERCP) usually provides an adequate map to plan the endoscopic therapy. After traversing the stricture with a guidewire and, occasionally, performing balloon dilatation, plastic stents continue to be the basic endotherapy, trying to insert the maximum possible number, with an exchange every 3 months during a 12-month period. Progressive stenting requires a median number of five ERCPs; therefore, it is technically demanding and burdensome but has an average of 80% long-term durable stricture dilation. For not-hilar BBS, fully covered self-expanding metal stents (FCSEMSs) are emerging as a promising therapy needing fewer of the endoscopist's technical skills and reducing ERCP procedures and, probably, costs. To equal a 10-mm diameter provided by a single FCSEMS, about three plastic stents placed side-by-side are needed. Manufacturers are working to improve FCSEMS designs to reduce migration rate and to allow an easy extraction after several months in place. Many studies have tried to show reproducible protocols for the duration of FCSEMS therapy and the results in different types of BBSs.