Literature DB >> 23850666

The influence of R substituents in triphenylphosphinegold(I) carbonimidothioates, Ph3PAu[SC(OR)=NPh] (R=Me, Et and iPr), upon in vitro cytotoxicity against the HT-29 colon cancer cell line and upon apoptotic pathways.

Chien Ing Yeo1, Kah Kooi Ooi, Abdah Md Akim, Kok Pian Ang, Zainal Abidin Fairuz, Siti Nadiah Binti Abdul Halim, Seik Weng Ng, Hoi-Ling Seng, Edward R T Tiekink.   

Abstract

The Ph3PAu[SC(OR)=NPh], R=Me (1), Et (2) and iPr (3), compounds are significantly cytotoxic to the HT-29 cancer cell line with 1 being the most active. Based on human apoptosis PCR-array analysis, caspase activities, DNA fragmentation, cell apoptotic assays, intracellular reactive oxygen species (ROS) measurements and human topoisomerase I inhibition, induction of apoptosis is demonstrated and both the extrinsic and intrinsic pathways of apoptosis have been shown to occur. Compound 1 activates the p73 gene, whereas each of 2 and 3 activates the p53 gene. An additional apoptotic mechanism is exhibited by 2, that is, via the JNK/MAP pathway.
Copyright © 2013 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Apoptosis; Cancer; Carbonimidothioate; Cell cycle; Phosphinegold(I) compounds; Thiolate

Mesh：

Substances：

Year:  2013        PMID： 23850666     DOI： 10.1016/j.jinorgbio.2013.05.011

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  10 in total

1.  Phosphanegold(I) thiolates, Ph3PAu[SC(OR)=NC 6H 4Me-4] for R = Me, Et and iPr, induce apoptosis, cell cycle arrest and inhibit cell invasion of HT-29 colon cancer cells through modulation of the nuclear factor-κB activation pathway and ubiquitination.

Authors:  Kah Kooi Ooi; Chien Ing Yeo; Kok-Pian Ang; Abdah Md Akim; Yoke-Kqueen Cheah; Siti Nadiah Abdul Halim; Hoi-Ling Seng; Edward R T Tiekink
Journal:  J Biol Inorg Chem       Date:  2015-05-24       Impact factor: 3.358

2.  Crystal structure of bis-[μ-bis-(di-phenyl-phosphanyl)methane-κ(2) P:P']digold(I) dichloride acetone monosolvate monohydrate.

Authors:  Chien Ing Yeo; Yee Seng Tan; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-07-17

3.  A monoclinic polymorph of [(Z)-N-(3-chloro-phen-yl)-O-methyl-thio-carbamato-κS](tri-phenyl-phosphane-κP)gold(I): crystal structure and Hirshfeld surface analysis.

Authors:  Chien Ing Yeo; Sang Loon Tan; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-07-07

4.  A non-solvated form of [(Z)-O-methyl-N-(2-methyl-phen-yl)-thio-carbamato-κS](tri-phenyl-phosphane-κP)gold(I): crystal structure and Hirshfeld surface analysis.

Authors:  Chien Ing Yeo; Sang Loon Tan; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-09-16

5.  New monoclinic form of {O-Ethyl N-(4-nitro-phen-yl)thio-carbamato-κS}(tri-4-tolyl-phosphane-κP)gold(I): crystal structure and Hirshfeld surface analysis.

Authors:  Fong Sheen Kuan; Mukesh M Jotani; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-09-15

6.  The effects of phosphanegold(I) thiolates on the biological properties of Acanthamoeba castellanii belonging to the T4 genotype.

Authors:  Ruqaiyyah Siddiqui; Farhat Abjani; Chien Ing Yeo; Edward R T Tiekink; Naveed Ahmed Khan
Journal:  J Negat Results Biomed       Date:  2017-04-03

Review 7.  Gold as a Possible Alternative to Platinum-Based Chemotherapy for Colon Cancer Treatment.

Authors:  Inés Mármol; Javier Quero; María Jesús Rodríguez-Yoldi; Elena Cerrada
Journal:  Cancers (Basel)       Date:  2019-06-05       Impact factor: 6.639

8.  Crystal structure of 1-(4-methyl-phen-yl)-3-(propan-2-yl-idene-amino)-thio-urea.

Authors:  Mukesh M Jotani; Chien Ing Yeo; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-09-26

9.  Crystal structures of 5-amino-N-phenyl-3H-1,2,4-di-thia-zol-3-iminium chloride and 5-amino-N-(4-chloro-phen-yl)-3H-1,2,4-di-thia-zol-3-iminium chloride monohydrate.

Authors:  Chien Ing Yeo; Yee Seng Tan; Edward R T Tiekink
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-09-12

Review 10.  Gold-Based Medicine: A Paradigm Shift in Anti-Cancer Therapy?

Authors:  Chien Ing Yeo; Kah Kooi Ooi; Edward R T Tiekink
Journal:  Molecules       Date:  2018-06-11       Impact factor: 4.411
  10 in total

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