OBJECTIVES: To determine the quantitative diagnostic capability of magnetic resonance imaging (MRI), compared to dual-energy X-ray absorptiometry (DEXA), for osteoporosis. MATERIALS AND METHODS: Eight male volunteers and eight patients underwent both DEXA and MRI. Results were obtained from each subject's L2 to L4, for a total of 48 lumbar vertebrae. Based on their bone mineral density (BMD) acquired from DEXA, the vertebrae were classified as follows: normal (n=28), osteopenic (n=0), and osteoporotic (n=20). All MR examinations were performed on a 1.5-T scanner to obtain T1-weighted imaging (T1WI), fat-suppression T2-weighted imaging (FS-T2WI), and diffusion-weighted imaging (DWI). These quantitative MR parameters were determined: T1WI and FS-T2WI signal-to-noise ratios and DWI apparent diffusion coefficient values. To determine the diagnostic capability of MRI as an osteoporosis indicator, MR parameters were assessed statistically. RESULTS: All MR parameters significantly correlated with BMD (T1WI: r=-0.64, FS-T2WI: r=-0.36, DWI: r=-0.29), with significant differences among normal and osteoporotic vertebrae (P<.05). By receiver operating characteristic analysis, the area under the curve of T1WI was significantly higher than others (P<.05). When adapted as feasible threshold values, sensitivity, specificity, and accuracy of T1WI were 95.0% (19/20), 92.9% (26/28), and 93.8% (45/48), respectively. CONCLUSION: Routine MRI, in particular T1WI, had a potential for the assessment of osteoporosis.
OBJECTIVES: To determine the quantitative diagnostic capability of magnetic resonance imaging (MRI), compared to dual-energy X-ray absorptiometry (DEXA), for osteoporosis. MATERIALS AND METHODS: Eight male volunteers and eight patients underwent both DEXA and MRI. Results were obtained from each subject's L2 to L4, for a total of 48 lumbar vertebrae. Based on their bone mineral density (BMD) acquired from DEXA, the vertebrae were classified as follows: normal (n=28), osteopenic (n=0), and osteoporotic (n=20). All MR examinations were performed on a 1.5-T scanner to obtain T1-weighted imaging (T1WI), fat-suppression T2-weighted imaging (FS-T2WI), and diffusion-weighted imaging (DWI). These quantitative MR parameters were determined: T1WI and FS-T2WI signal-to-noise ratios and DWI apparent diffusion coefficient values. To determine the diagnostic capability of MRI as an osteoporosis indicator, MR parameters were assessed statistically. RESULTS: All MR parameters significantly correlated with BMD (T1WI: r=-0.64, FS-T2WI: r=-0.36, DWI: r=-0.29), with significant differences among normal and osteoporotic vertebrae (P<.05). By receiver operating characteristic analysis, the area under the curve of T1WI was significantly higher than others (P<.05). When adapted as feasible threshold values, sensitivity, specificity, and accuracy of T1WI were 95.0% (19/20), 92.9% (26/28), and 93.8% (45/48), respectively. CONCLUSION: Routine MRI, in particular T1WI, had a potential for the assessment of osteoporosis.
Authors: Mohammad Momeni; Mohammad Asadzadeh; Karim Mowla; Mohammad Ghasem Hanafi; Mohammad Momen Gharibvand; Aliakbar Sahraeizadeh Journal: Radiol Med Date: 2019-09-17 Impact factor: 3.469
Authors: Evgenii Belykh; Andrey A Kalinin; Arpan A Patel; Eric J Miller; Michael A Bohl; Ivan A Stepanov; Liudmila A Bardonova; Talgat Kerimbaev; Anton O Asantsev; Morgan B Giers; Mark C Preul; Vadim A Byvaltsev Journal: PLoS One Date: 2017-08-28 Impact factor: 3.240