Literature DB >> 23835491

Colorectal cancer: Cascade genetic testing in Lynch syndrome: room for improvement.

Kory Jasperson1.   

Abstract

Genetic testing in relatives of individuals with Lynch syndrome is of utmost importance for targeted screening and prevention. A recent systematic review suggests that the uptake of testing in at-risk relatives is inadequate and therefore the cost-effectiveness of Lynch syndrome testing is questionable. The results of this study are discussed here.

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Mesh：

Year:  2013        PMID： 23835491     DOI： 10.1038/nrgastro.2013.122

Source DB:  PubMed          Journal:  Nat Rev Gastroenterol Hepatol        ISSN： 1759-5045            Impact factor:   46.802


  6 in total

1.  Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction.

Authors:  K Aktan-Collan; J P Mecklin; H Järvinen; M Nyström-Lahti; P Peltomäki; I Söderling; A Uutela; A de la Chapelle; H Kääriäinen
Journal:  Int J Cancer       Date:  2000-01-20       Impact factor: 7.396

2.  Life events may contribute to family communication about cancer risk following BRCA1/2 testing.

Authors:  Julie Lapointe; Claudia Côté; Karine Bouchard; Béatrice Godard; Jacques Simard; Michel Dorval
Journal:  J Genet Couns       Date:  2012-08-15       Impact factor: 2.537

Review 3.  Uptake of genetic testing by relatives of lynch syndrome probands: a systematic review.

Authors:  Ravi N Sharaf; Parvathi Myer; Christopher D Stave; Lisa C Diamond; Uri Ladabaum
Journal:  Clin Gastroenterol Hepatol       Date:  2013-05-10       Impact factor: 11.382

4.  Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives.

Authors: 
Journal:  Genet Med       Date:  2009-01       Impact factor: 8.822

5.  Implementing screening for Lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting.

Authors:  Cecelia A Bellcross; Sara R Bedrosian; Elvan Daniels; Debra Duquette; Heather Hampel; Kory Jasperson; Djenaba A Joseph; Celia Kaye; Ira Lubin; Laurence J Meyer; Michele Reyes; Maren T Scheuner; Sheri D Schully; Leigha Senter; Sherri L Stewart; Jeanette St Pierre; Judith Westman; Paul Wise; Vincent W Yang; Muin J Khoury
Journal:  Genet Med       Date:  2011-10-27       Impact factor: 8.822

6.  The cost-effectiveness of genetic testing strategies for Lynch syndrome among newly diagnosed patients with colorectal cancer.

Authors:  Mercy Mvundura; Scott D Grosse; Heather Hampel; Glenn E Palomaki
Journal:  Genet Med       Date:  2010-02       Impact factor: 8.822
  6 in total
  3 in total

1.  The uptake of presymptomatic genetic testing in hereditary breast-ovarian cancer and Lynch syndrome: a systematic review of the literature and implications for clinical practice.

Authors:  Fred H Menko; Jacqueline A Ter Stege; Lizet E van der Kolk; Kiki N Jeanson; Winnie Schats; Daoud Ait Moha; Eveline M A Bleiker
Journal:  Fam Cancer       Date:  2019-01       Impact factor: 2.375

Review 2.  The genetic basis of Lynch syndrome and its implications for clinical practice and risk management.

Authors:  Stephanie A Cohen; Anna Leininger
Journal:  Appl Clin Genet       Date:  2014-07-22

3.  Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome.

Authors:  Donald W Hadley; Dina Eliezer; Yonit Addissie; Andrea Goergen; Sato Ashida; Laura Koehly
Journal:  Sci Rep       Date:  2020-09-29       Impact factor: 4.379
  3 in total

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