| Literature DB >> 23817571 |
Klaus Bønnelykke1, Melanie C Matheson2, Tune H Pers3,4,5,6, Raquel Granell7, David P Strachan8, Alexessander Couto Alves9, Allan Linneberg10, John A Curtin11, Nicole M Warrington12, Marie Standl13, Marjan Kerkhof14, Ingileif Jonsdottir15,16, Blazenka K Bukvic17, Marika Kaakinen18,19, Patrick Sleimann20,21, Gudmar Thorleifsson15, Unnur Thorsteinsdottir15,16, Katharina Schramm22, Svetlana Baltic23,24, Eskil Kreiner-Møller1, Angela Simpson11, Beate St Pourcain7, Lachlan Coin9, Jennie Hui25,26,27,28, Eugene H Walters29, Carla M T Tiesler13, David L Duffy30, Graham Jones31, Susan M Ring7, Wendy L McArdle7,8, Loren Price23,24, Colin F Robertson32, Juha Pekkanen33,34, Clara S Tang30, Elisabeth Thiering13, Grant W Montgomery30, Anna-Liisa Hartikainen35, Shyamali C Dharmage2, Lise L Husemoen10, Christian Herder36, John P Kemp7, Paul Elliot9, Alan James28,37,38, Melanie Waldenberger39, Michael J Abramson40, Benjamin P Fairfax41, Julian C Knight41, Ramneek Gupta3, Philip J Thompson23,24, Patrick Holt42,43, Peter Sly44, Joel N Hirschhorn6,45,4,46, Mario Blekic17, Stephan Weidinger47, Hakon Hakonarsson20,21, Kari Stefansson15,16, Joachim Heinrich13, Dirkje S Postma48, Adnan Custovic11, Craig E Pennell12, Marjo-Riitta Jarvelin18,19,49,50,51, Gerard H Koppelman52, Nicholas Timpson7, Manuel A Ferreira30, Hans Bisgaard1, A John Henderson7.
Abstract
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.Entities:
Mesh：
Year: 2013 PMID： 23817571 PMCID： PMC4922420 DOI： 10.1038/ng.2694
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330