INTRODUCTION: Cachexia is a multifatorial syndrome characterized by loss of body weight, fat and muscle, increasing morbidity and mortality. The use of an index accounting for both serum albumin and C Reactive Protein levels could make early identification of cachexia easier. OBJECTIVE: To evaluate the variation of an inflammatory nutritional index related to nutritional status in cancer patients. METHODS: Cross sectional study including patients with gastrointestinal and lung cancer of a public chemotherapy service in Brazil. Serum albumin and C Reactive Protein were measured and the nutritional status was defined by Subjective Global Assessment. Statistical analyses were performed using Stata 9.2(TM). RESULTS: A total of 74 patients were evaluated, 58.1% of them were male, mean age 63.4 ± 11.9 years old. Gastrointestinal cancer was the most prevalent type (71.6%). Only 13.7% of the patients were well nourished and 21.9% were severely malnourished. C Reactive Protein significantly increased according to nutritional status decline (p=0.03). When the albumin from patients with systemic inflammation was evaluated, there was no significant variation in relation to nutritional status (p=0.06). The Inflammatory Nutritional Index significantly varied in relation to nutritional status independent of the systemic inflammation (p=0.02). CONCLUSIONS: Inflammatory Nutritional Index can be an adjuvant way for biochemical nutritional assessment and follow up in cancer patients with systemic inflammation.
INTRODUCTION:Cachexia is a multifatorial syndrome characterized by loss of body weight, fat and muscle, increasing morbidity and mortality. The use of an index accounting for both serum albumin and C Reactive Protein levels could make early identification of cachexia easier. OBJECTIVE: To evaluate the variation of an inflammatory nutritional index related to nutritional status in cancerpatients. METHODS: Cross sectional study including patients with gastrointestinal and lung cancer of a public chemotherapy service in Brazil. Serum albumin and C Reactive Protein were measured and the nutritional status was defined by Subjective Global Assessment. Statistical analyses were performed using Stata 9.2(TM). RESULTS: A total of 74 patients were evaluated, 58.1% of them were male, mean age 63.4 ± 11.9 years old. Gastrointestinal cancer was the most prevalent type (71.6%). Only 13.7% of the patients were well nourished and 21.9% were severely malnourished. C Reactive Protein significantly increased according to nutritional status decline (p=0.03). When the albumin from patients with systemic inflammation was evaluated, there was no significant variation in relation to nutritional status (p=0.06). The Inflammatory Nutritional Index significantly varied in relation to nutritional status independent of the systemic inflammation (p=0.02). CONCLUSIONS: Inflammatory Nutritional Index can be an adjuvant way for biochemical nutritional assessment and follow up in cancerpatients with systemic inflammation.
Authors: Hui-Yi Lin; Qiufan Fu; Yu-Hsiang Kao; Tung-Sung Tseng; Krzysztof Reiss; Jennifer E Cameron; Martin J Ronis; Joseph Su; Navya Nair; Hsiao-Man Chang; Michael E Hagensee Journal: J Infect Dis Date: 2021-11-16 Impact factor: 5.226
Authors: Marine Perrier; Marie-Amelie Ordan; Coralie Barbe; Camille Mazza; Damien Botsen; Johanna Moreau; Yohann Renard; Mathilde Brasseur; Barbara Tailliere; Philippe Regnault; Eric Bertin; Olivier Bouche Journal: Support Care Cancer Date: 2021-07-12 Impact factor: 3.603
Authors: Soo Liang Ooi; Sok Cheon Pak; Peter S Micalos; Emily Schupfer; Rob Zielinski; Thomas Jeffries; Garth Harris; Terry Golombick; David McKinnon Journal: Contemp Clin Trials Commun Date: 2020-05-29