Hui-Yi Lin1, Qiufan Fu1, Yu-Hsiang Kao2, Tung-Sung Tseng2, Krzysztof Reiss3, Jennifer E Cameron4, Martin J Ronis5, Joseph Su6, Navya Nair7, Hsiao-Man Chang8, Michael E Hagensee9. 1. Biostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. 2. Behavior and Community Health Sciences Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. 3. Department of Hematology and Oncology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. 4. Department of Microbiology, Immunology & Parasitology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. 5. Department of Pharmacology & Experimental Therapeutics, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. 6. Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. 7. Department of Obstetrics and Gynecology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. 8. Emory University, Atlanta, Georgia, USA. 9. Section of Infection Diseases, Department of Medicine, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.
Abstract
BACKGROUND: Human papillomavirus (HPV) infection is a major cause of cervical cancer. Studies showed the onset of HPV carcinogenesis may be induced by oxidative stress affecting the host immune system. The association between antioxidants and oncogenic HPV remains unclear. In this study, we aim to identify antioxidants associated with vaginal HPV infection in women. METHODS: The associations between the 15 antioxidants and vaginal HPV infection status (no, low-risk [LR], and high-risk [HR] HPV) were evaluated using 11 070 women who participated in the 2003-2016 National Health and Nutrition Examination Survey (NHANES). RESULTS: We identified serum albumin and 4 dietary antioxidants (vitamin A, B2, E, and folate) inversely associated with HR-HPV infection. Women with a low level of albumin (≤39 g/L) have a significantly higher risk of HR-HPV (odds ratio [OR] = 1.4, P = .009 vs >44 g/L). A Nutritional Antioxidant Score (NAS) was developed based on these 4 dietary antioxidants. The women with the lowest quartile NAS had a higher chance of HR-HPV (OR = 1.3, P = .030) and LR-HPV (OR = 1.4, P = .002) compared with the women with the highest quartile NAS. CONCLUSIONS: We identified 5 antioxidants negatively associated with vaginal HR-HPV infection in women. Our findings provide valuable insights into understanding antioxidants' impact on HPV carcinogenesis.
BACKGROUND: Human papillomavirus (HPV) infection is a major cause of cervical cancer. Studies showed the onset of HPV carcinogenesis may be induced by oxidative stress affecting the host immune system. The association between antioxidants and oncogenic HPV remains unclear. In this study, we aim to identify antioxidants associated with vaginal HPV infection in women. METHODS: The associations between the 15 antioxidants and vaginal HPV infection status (no, low-risk [LR], and high-risk [HR] HPV) were evaluated using 11 070 women who participated in the 2003-2016 National Health and Nutrition Examination Survey (NHANES). RESULTS: We identified serum albumin and 4 dietary antioxidants (vitamin A, B2, E, and folate) inversely associated with HR-HPV infection. Women with a low level of albumin (≤39 g/L) have a significantly higher risk of HR-HPV (odds ratio [OR] = 1.4, P = .009 vs >44 g/L). A Nutritional Antioxidant Score (NAS) was developed based on these 4 dietary antioxidants. The women with the lowest quartile NAS had a higher chance of HR-HPV (OR = 1.3, P = .030) and LR-HPV (OR = 1.4, P = .002) compared with the women with the highest quartile NAS. CONCLUSIONS: We identified 5 antioxidants negatively associated with vaginal HR-HPV infection in women. Our findings provide valuable insights into understanding antioxidants' impact on HPV carcinogenesis.
Authors: Hyun-Woong Cho; Yung-Taek Ouh; Jin Hwa Hong; Kyung Jin Min; Kyeong A So; Tae Jin Kim; E Sun Paik; Jeong-Won Lee; Jun Hye Moon; Jae Kwan Lee Journal: J Virol Methods Date: 2019-04-15 Impact factor: 2.014
Authors: S Rachel Skinner; Cosette M Wheeler; Barbara Romanowski; Xavier Castellsagué; Eduardo Lazcano-Ponce; M Rowena Del Rosario-Raymundo; Carlos Vallejos; Galina Minkina; Daniel Pereira Da Silva; Shelly McNeil; Vera Prilepskaya; Irina Gogotadze; Deborah Money; Suzanne M Garland; Viktor Romanenko; Diane M Harper; Myron J Levin; Archana Chatterjee; Brecht Geeraerts; Frank Struyf; Gary Dubin; Marie-Cécile Bozonnat; Dominique Rosillon; Laurence Baril Journal: Int J Cancer Date: 2016-05-15 Impact factor: 7.396