Cationic Rh(II) complexes are able to catalyze the regioselective hydroamination of propargyl ureas in a 6-endo fashion. This transformation permits access to interesting substitution patterns of dihydropyrimidines which have found use as nucleotide exchange factor inhibitors.
Cationic pan class="Gene">Rh(II) complexes are able to catalyze the regioselective hydroamination of propargyl ureas in a 6-endo fashion. This transformation permits access to interesting substitution patterns of pan class="Chemical">dihydropyrimidines which have found use as nucleotide exchange factor inhibitors.
Authors: Vsevolod A Peshkov; Olga P Pereshivko; Sweta Sharma; Thirumal Meganathan; Virinder S Parmar; Denis S Ermolat'ev; Erik V Van der Eycken Journal: J Org Chem Date: 2011-06-15 Impact factor: 4.354
Authors: Jan-Philipp Berndt; Yevhenii Radchenko; Jonathan Becker; Christian Logemann; Dhaka R Bhandari; Radim Hrdina; Peter R Schreiner Journal: Chem Sci Date: 2019-02-06 Impact factor: 9.825