Literature DB >> 19149663

Genesis of dihydropyrimidinone(psi) calcium channel blockers: recent progress in structure-activity relationships and other effects.

K Singh1, D Arora, K Singh1, S Singh.   

Abstract

In the armamentarium of calcium channel blockers appropriately functionalized 3,4-dihydropyrimidin-2(1H)-ones have received considerable attention in recent past owing to their structural similarity with 1,4-dihydropyridine based drugs. In this review, we highlight detailed investigations in the calcium channel blocking and other activities of this category of compounds as well as trace their genesis from 1,4-dihydropyridine based drugs.

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Year:  2009        PMID： 19149663     DOI： 10.2174/138955709787001686

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  7 in total

1.  Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas.

Authors:  Miao Yang; Shannon J Odelberg; Zongzhong Tong; Dean Y Li; Ryan E Looper
Journal:  Tetrahedron       Date:  2013-07-08       Impact factor: 2.457

2.  Enantioselective rhodium-catalyzed [4+2] cycloaddition of α,β-unsaturated imines and isocyanates.

Authors:  Kevin M Oberg; Tomislav Rovis
Journal:  J Am Chem Soc       Date:  2011-03-14       Impact factor: 15.419

3.  An efficacious protocol for C-4 substituted 3,4-dihydropyrimidinones. Synthesis and calcium channel binding studies.

Authors:  Kamaljit Singh; Divya Arora; Danielle Falkowski; Qingxin Liu; Robert S Moreland
Journal:  European J Org Chem       Date:  2009-07-01

4.  Secondary amine-initiated three-component synthesis of 3,4-dihydropyrimidinones and thiones involving alkynes, aldehydes and thiourea/urea.

Authors:  Jie-Ping Wan; Yunfang Lin; Kaikai Hu; Yunyun Liu
Journal:  Beilstein J Org Chem       Date:  2014-01-29       Impact factor: 2.883

5.  Biginelli reaction catalyzed by copper nanoparticles.

Authors:  Manika Dewan; Ajeet Kumar; Amit Saxena; Arnab De; Subho Mozumdar
Journal:  PLoS One       Date:  2012-08-17       Impact factor: 3.240

6.  Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions.

Authors:  Trevor A Hamlin; Nicholas E Leadbeater
Journal:  Beilstein J Org Chem       Date:  2013-09-11       Impact factor: 2.883

7.  Magnetic core-shell Carrageenan moss/Fe3O4: a polysaccharide-based metallic nanoparticles for synthesis of pyrimidinone derivatives via Biginelli reaction.

Authors:  Hossein Mohammad Zaheri; Shahrzad Javanshir; Behnaz Hemmati; Zahra Dolatkhah; Maryam Fardpour
Journal:  Chem Cent J       Date:  2018-10-27       Impact factor: 4.215
  7 in total

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