| Literature DB >> 2379630 |
H Meinertz1, L Linnet, P Fogh-Andersen, T Hjort.
Abstract
A group of 216 vasovasostomized men were tested with the mixed antiglobulin reaction for immunoglobulin (Ig)G, IgA, and secretory IgA antisperm antibodies bound to the sperm membrane. Free antisperm antibodies in serum and seminal plasma were detected with the gelatin agglutination test and the tray agglutination test. The results were related to the conception rates. In a subgroup with a pure IgG response, the conception rate reached 85.7%, whereas only 42.9% of the men who also had IgA on the sperm induced pregnancy. When 100% of the spermatozoa were covered with IgA, the conception rate was reduced to 21.7%. The combination of IgA on all sperm and a strong immune response (titer in serum greater than or equal to 256) was associated with a conception rate of zero.Entities:
Keywords: Antibodies--analysis; Biology; Birth Rate; Data Collection; Demographic Factors; Examinations And Diagnoses; Family Planning; Fertility; Fertility Measurements; Fertility Rate; Follow-up Studies; Genitalia; Genitalia, Male; Immunity; Immunologic Factors; Immunological Effects; Laboratory Examinations And Diagnoses; Physiology; Population; Population Dynamics; Research Methodology; Reversible Sterilization; Semen--analysis; Seminal Vesicles; Sterilization Reversal; Sterilization, Sexual; Studies; Urogenital System; Vas Reanastomosis
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Year: 1990 PMID： 2379630
Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329