| Literature DB >> 23793030 |
Quan Long1, Fernando A Rabanal1, Dazhe Meng2, Christian D Huber3, Ashley Farlow1, Alexander Platzer1, Qingrun Zhang1, Bjarni J Vilhjálmsson2, Arthur Korte1, Viktoria Nizhynska1, Viktor Voronin1, Pamela Korte1, Laura Sedman1, Terezie Mandáková4, Martin A Lysak4, Ümit Seren1, Ines Hellmann3, Magnus Nordborg1,2.
Abstract
Despite advances in sequencing, the goal of obtaining a comprehensive view of genetic variation in populations is still far from reached. We sequenced 180 lines of A. thaliana from Sweden to obtain as complete a picture as possible of variation in a single region. Whereas simple polymorphisms in the unique portion of the genome are readily identified, other polymorphisms are not. The massive variation in genome size identified by flow cytometry seems largely to be due to 45S rDNA copy number variation, with lines from northern Sweden having particularly large numbers of copies. Strong selection is evident in the form of long-range linkage disequilibrium (LD), as well as in LD between nearby compensatory mutations. Many footprints of selective sweeps were found in lines from northern Sweden, and a massive global sweep was shown to have involved a 700-kb transposition.Entities:
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Year: 2013 PMID： 23793030 PMCID： PMC3755268 DOI： 10.1038/ng.2678
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307