Literature DB >> 23781493

A Rapid, Quantitative Method to Characterize The Human Lymphocyte Concentration for Automated High-Throughput Radiation Biodosimetry.

Yanping Xu1, Helen C Turner, Guy Garty, David Brenner.   

Abstract

We have developed a Quantitative Light Absorption Analysis (QLAA) method to rapidly estimate human lymphocyte concentrations isolated from small volumes of whole blood. Measurements of the light absorption analysis were calibrated for lymphocyte concentration levels using a hemocytometer. To validate the QLAA system, blood samples were collected from 17 healthy donors and lymphocyte absorption measurements were directly compared with the manual microscope counting. The results showed that lymphocyte measurements obtained using the QLAA system were comparable with the manually scored lymphocyte counts but with measurements taken in seconds.

Entities:  

Keywords:  QLAA; lymphocyte; radiation RABiT

Year:  2013        PMID： 23781493      PMCID： PMC3683596          DOI： 10.5963/ber0201002

Source DB:  PubMed          Journal:  Biomed Eng Res        ISSN： 2306-5990


  6 in total

1.  Quantitative buffy coat analysis. A new laboratory tool functioning as a screening complete blood cell count.

Authors:  S C Wardlaw; R A Levine
Journal:  JAMA       Date:  1983-02-04       Impact factor: 56.272

2.  The RABiT: a rapid automated biodosimetry tool for radiological triage. II. Technological developments.

Authors:  Guy Garty; Youhua Chen; Helen C Turner; Jian Zhang; Oleksandra V Lyulko; Antonella Bertucci; Yanping Xu; Hongliang Wang; Nabil Simaan; Gerhard Randers-Pehrson; Y Lawrence Yao; David J Brenner
Journal:  Int J Radiat Biol       Date:  2011-05-11       Impact factor: 2.694

3.  Hematological values from quantitative buffy coat analysis (QBC II) system: evaluation in a hematological/oncological outpatient section.

Authors:  A Riccardi; M Danova; L Quartero; M Besozzi; E Molinari; S Brugnatelli; E Ascari
Journal:  Haematologica       Date:  1989 Jul-Aug       Impact factor: 9.941

4.  Adapting the γ-H2AX assay for automated processing in human lymphocytes. 1. Technological aspects.

Authors:  Helen C Turner; David J Brenner; Youhua Chen; Antonella Bertucci; Jian Zhang; Hongliang Wang; Oleksandra V Lyulko; Yanping Xu; Igor Shuryak; Julia Schaefer; Nabil Simaan; Gerhard Randers-Pehrson; Y Lawrence Yao; Sally A Amundson; Guy Garty
Journal:  Radiat Res       Date:  2010-12-28       Impact factor: 2.841

5.  Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group.

Authors:  Jamie K Waselenko; Thomas J MacVittie; William F Blakely; Nicki Pesik; Albert L Wiley; William E Dickerson; Horace Tsu; Dennis L Confer; C Norman Coleman; Thomas Seed; Patrick Lowry; James O Armitage; Nicholas Dainiak
Journal:  Ann Intern Med       Date:  2004-06-15       Impact factor: 25.391

6.  The RABIT: a rapid automated biodosimetry tool for radiological triage.

Authors:  Guy Garty; Youhua Chen; Alessio Salerno; Helen Turner; Jian Zhang; Oleksandra Lyulko; Antonella Bertucci; Yanping Xu; Hongliang Wang; Nabil Simaan; Gerhard Randers-Pehrson; Y Lawrence Yao; Sally A Amundson; David J Brenner
Journal:  Health Phys       Date:  2010-02       Impact factor: 1.316
  6 in total
  6 in total

Review 1.  Metabolomic applications in radiation biodosimetry: exploring radiation effects through small molecules.

Authors:  Evan L Pannkuk; Albert J Fornace; Evagelia C Laiakis
Journal:  Int J Radiat Biol       Date:  2017-01-12       Impact factor: 2.694

2.  Advances in a framework to compare bio-dosimetry methods for triage in large-scale radiation events.

Authors:  Ann Barry Flood; Holly K Boyle; Gaixin Du; Eugene Demidenko; Roberto J Nicolalde; Benjamin B Williams; Harold M Swartz
Journal:  Radiat Prot Dosimetry       Date:  2014-04-11       Impact factor: 0.972

3.  Developments in Biodosimetry Methods for Triage With a Focus on X-band Electron Paramagnetic Resonance In Vivo Fingernail Dosimetry.

Authors:  Steven G Swarts; Jason W Sidabras; Oleg Grinberg; Dmitriy S Tipikin; Maciej M Kmiec; Sergey V Petryakov; Wilson Schreiber; Victoria A Wood; Benjamin B Williams; Ann Barry Flood; Harold M Swartz
Journal:  Health Phys       Date:  2018-07       Impact factor: 1.316

4.  The RABiT: high-throughput technology for assessing global DSB repair.

Authors:  Helen C Turner; P Sharma; J R Perrier; A Bertucci; L Smilenov; G Johnson; M Taveras; D J Brenner; G Garty
Journal:  Radiat Environ Biophys       Date:  2014-01-30       Impact factor: 1.925

Review 5.  Scientific and Logistical Considerations When Screening for Radiation Risks by Using Biodosimetry Based on Biological Effects of Radiation Rather than Dose: The Need for Prior Measurements of Homogeneity and Distribution of Dose.

Authors:  Harold M Swartz; Ann Barry Flood; Vijay K Singh; Steven G Swarts
Journal:  Health Phys       Date:  2020-07       Impact factor: 2.922

6.  An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival.

Authors:  Antoine M Snijders; Sasha Langley; Jian-Hua Mao; Sandhya Bhatnagar; Kathleen A Bjornstad; Chris J Rosen; Alvin Lo; Yurong Huang; Eleanor A Blakely; Gary H Karpen; Mina J Bissell; Andrew J Wyrobek
Journal:  Oncotarget       Date:  2014-06-30
  6 in total

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