Literature DB >> 23779110

Biological implications and regulatory mechanisms of long-range chromosomal interactions.

Zong Wei1, David Huang, Fan Gao, Wen-Hsuan Chang, Woojin An, Gerhard A Coetzee, Kai Wang, Wange Lu.   

Abstract

Development of high-throughput sequencing-based methods has enabled us to examine nuclear architecture at unprecedented resolution, allowing further examination of the function of long-range chromosomal interactions. Here, we review methods used to investigate novel long-range chromosomal interactions and genome-wide organization of chromatin. We further discuss transcriptional activation and silencing in relation to organization and positioning of gene loci and regulation of chromatin organization through protein complexes and noncoding RNAs.

Keywords:  Chromatin; Chromatin Regulation; Chromatin Structure; Chromosome Conformation Capture; Nuclear Organization; Nuclear Structure

Mesh:

Substances:

Year:  2013        PMID: 23779110      PMCID: PMC3829327          DOI: 10.1074/jbc.R113.485292

Source DB:  PubMed          Journal:  J Biol Chem        ISSN: 0021-9258            Impact factor:   5.157


  98 in total

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