Literature DB >> 23768

Phospholipase A activity associated with membranes of human polymorphonuclear leucocytes.

R Franson, J Weiss, L Martin, J K Spitznagel, P Elsbach.   

Abstract

Homogenates of human polymorphonuclear leucocytes (granulocytes) contain a Ca2+-dependent phospholipase A with optimal activity pH7.0. This enzyme is membrane-bound and is enriched in crude cytoplasmic-granule fraction. Ratezonal centrifugation of the cytoplasmic-granule fraction demonstrates that the phospholipase A is associated not only with specific- and azurophilic-granule populations but also with an 'empty' vesicular fraction containing 85% of the total alkaline phosphatase activity of whole homogenate. Thus this phospholipase is associated with granule as well as with other cellular membranes of human granulocytes.

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Year:  1977        PMID： 23768      PMCID： PMC1183734          DOI： 10.1042/bj1670839

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  12 in total

1.  A rapid method of total lipid extraction and purification.

Authors:  E G BLIGH; W J DYER
Journal:  Can J Biochem Physiol       Date:  1959-08

2.  Leukocyte preparations from human blood: evaluation of their morphologic and metabolic state.

Authors:  H J FALLON; E FREI; J D DAVIDSON; J S TRIER; D BURK
Journal:  J Lab Clin Med       Date:  1962-05

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Character of azurophil and specific granules purified from human polymorphonuclear leukocytes.

Authors:  J K Spitznagel; F G Dalldorf; M S Leffell; J D Folds; I R Welsh; M H Cooney; L E Martin
Journal:  Lab Invest       Date:  1974-06       Impact factor: 5.662

5.  Altered phospholipid metabolism in Escherichia coli accompanying killing by disrupted granulocytes.

Authors:  C Mooney; P Elsbach
Journal:  Infect Immun       Date:  1975-06       Impact factor: 3.441

6.  Partial characterization and purification of a rabbit granulocyte factor that increases permeability of Escherichia coli.

Authors:  J Weiss; R C Franson; S Beckerdite; K Schmeidler; P Elsbach
Journal:  J Clin Invest       Date:  1975-01       Impact factor: 14.808

7.  Identification and partial characterization of phospholipases in isolated adrenocortical cells. The effects of synacthen [corticotropin-(1--24)-tetracosapeptide] and calcium ions.

Authors:  S G Laychock; R C Franson; W B Weglicki; R P Rubin
Journal:  Biochem J       Date:  1977-06-15       Impact factor: 3.857

8.  Phospholipid metabolism by phagocytic cells. VII. The degradation and utilization of phospholipids of various microbial species by rabbit granulocytes.

Authors:  P Patriarca; S Beckerdite; P Pettis; P Elsbach
Journal:  Biochim Biophys Acta       Date:  1972-09-07

9.  Phospholipid metabolism by phagocytic cells. VI. Observations on the fate of phospholipids of granulocytes and ingested Escherichia coli during phagocytosis.

Authors:  P Elsbach; J Goldman; P Patriarca
Journal:  Biochim Biophys Acta       Date:  1972-09-07

10.  Phospholipid metabolism by phagocytic cells. Phospholipases A2 associated with rabbit polymorphonuclear leukocyte granules.

Authors:  R Franson; P Patriarca; P Elsbach
Journal:  J Lipid Res       Date:  1974-07       Impact factor: 5.922
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  11 in total

1.  Serum phospholipase A in hematological diseases.

Authors:  R T Hiefinger; W G Guder; G E Hoffmann
Journal:  Klin Wochenschr       Date:  1989-02-01

2.  Distribution of pancreatic (group I) and synovial-type (group II) phospholipases A2 in human tissues.

Authors:  T J Nevalainen; T J Haapanen
Journal:  Inflammation       Date:  1993-08       Impact factor: 4.092

3.  Neutrophil aggregation and degranulation. Effect of arachidonic acid.

Authors:  J T O'Flaherty; H J Showell; E L Becker; P A Ward
Journal:  Am J Pathol       Date:  1979-05       Impact factor: 4.307

4.  Phospholipid metabolism in human neutrophils activated by N-formyl-methionyl-leucyl-phenylalanine. Degranulation is not required for release of arachidonic acid: studies with neutrophils and neutrophil-derived cytoplasts.

Authors:  E M Wynkoop; M J Broekman; H M Korchak; A J Marcus; G Weissmann
Journal:  Biochem J       Date:  1986-06-15       Impact factor: 3.857

5.  Phospholipase A2 in human ascitic fluid. Purification, characterization and immunochemical detection.

Authors:  P T Kortesuo; T J Nevalainen
Journal:  Biochem J       Date:  1991-08-15       Impact factor: 3.857

6.  Electron microscopic study of phagocytosis of Escherichia coli by human polymorphonuclear leukocytes.

Authors:  M Rozenberg-Arska; M E Salters; J A van Strijp; J J Geuze; J Verhoef
Journal:  Infect Immun       Date:  1985-12       Impact factor: 3.441

7.  Release of phospholipase A2 activity from rabbit peritoneal neutrophils by f-Met-Leu-Phe.

Authors:  C Lanni; E L Becker
Journal:  Am J Pathol       Date:  1983-10       Impact factor: 4.307

8.  Renal inner medullary prostaglandin synthesis. A calcium-calmodulin-dependent process suppressed by urea.

Authors:  P A Craven; R K Studer; F R Derubertis
Journal:  J Clin Invest       Date:  1981-09       Impact factor: 14.808

9.  Prognostic value of serum phospholipase A in the multitraumatized patient.

Authors:  C Waydhas; D Nast-Kolb; K H Duswald; P Lehnert; L Schweiberer
Journal:  Klin Wochenschr       Date:  1989-02-01

Review 10.  Serum phospholipase--regulatory and pathophysiological aspects.

Authors:  G E Hoffmann; W G Guder
Journal:  Klin Wochenschr       Date:  1989-02-01
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