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Literature DB >> 23766892

Interactions between cellular proteins and morphologically different nanoscale aggregates of small molecules.

Yi Kuang¹, Dan Yuan, Ye Zhang, Anita Kao, Xuewen Du, Bing Xu.

Abstract

Depending on the methods of preparation, amphiphilic small molecules aggregate to form nanostructures with different morphologies that interact with cytosol proteins in a drastically different manner, thus illustrating the first example of morphological dependent protein binding of nanoscale molecular aggregates.

Entities: CellLine Chemical Disease Gene Species

Year: 2013 PMID： 23766892 PMCID： PMC3677794 DOI： 10.1039/C3RA41523F

Source DB: PubMed Journal: RSC Adv ISSN： 2046-2069 Impact factor: 3.361

19 in total

Review 1. Pathological and functional amyloid formation orchestrated by the secretory pathway.

Authors: Mary E Huff; William E Balch; Jeffery W Kelly
Journal: Curr Opin Struct Biol Date: 2003-12 Impact factor: 6.809

Review 2. Water gelation by small organic molecules.

Authors: Lara A Estroff; Andrew D Hamilton
Journal: Chem Rev Date: 2004-03 Impact factor: 60.622

Review 3. Cell mechanics and the cytoskeleton.

Authors: Daniel A Fletcher; R Dyche Mullins
Journal: Nature Date: 2010-01-28 Impact factor: 49.962

Review 4. Designing peptide based nanomaterials.

Authors: Rein V Ulijn; Andrew M Smith
Journal: Chem Soc Rev Date: 2008-01-10 Impact factor: 54.564

5. Using supramolecular hydrogels to discover the interactions between proteins and molecular nanofibers of small molecules.

Authors: Yuan Gao; Marcus J C Long; Junfeng Shi; Lizbeth Hedstrom; Bing Xu
Journal: Chem Commun (Camb) Date: 2012-07-17 Impact factor: 6.222

Interactions between cellular proteins and morphologically different nanoscale aggregates of small molecules.

Review 1. Pathological and functional amyloid formation orchestrated by the secretory pathway.

Review 2. Water gelation by small organic molecules.

Review 3. Cell mechanics and the cytoskeleton.

Review 4. Designing peptide based nanomaterials.

5. Using supramolecular hydrogels to discover the interactions between proteins and molecular nanofibers of small molecules.

6. Arrest of beta-amyloid fibril formation by a pentapeptide ligand.

7. Dipeptide hydrogelation triggered via ultraviolet light.

Review 8. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

9. Self-assembly and hydrogelation of an amyloid peptide fragment.

10. Neuroserpin binds Abeta and is a neuroprotective component of amyloid plaques in Alzheimer disease.

Review 1. Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials.

2. Prion-like nanofibrils of small molecules (PriSM) selectively inhibit cancer cells by impeding cytoskeleton dynamics.

Review 3. Supramolecular biofunctional materials.

Review 4. D-amino acid-containing supramolecular nanofibers for potential cancer therapeutics.

5. Nanoscale Assemblies of Small Molecules Control the Fate of Cells.

6. A naphthalene-containing amino acid enables hydrogelation of a conjugate of nucleobase-saccharide-amino acids.

7. The first supramolecular peptidic hydrogelator containing taurine.

8. Drug-free macromolecular therapeutics: Impact of structure on induction of apoptosis in Raji B cells.

9. Supramolecular nanofibrils inhibit cancer progression in vitro and in vivo.

Review 10. Supramolecular hydrogels made of basic biological building blocks.