PURPOSE: The aim of this study was to review the available literature and define clinical practice guidelines for the use of natural agents for the prevention and treatment of oral mucositis. METHODS: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible. RESULTS: A total of 49 papers across 15 interventions were examined. A new suggestion was developed in favor of systemic zinc supplements administered orally in the prevention of oral mucositis in oral cancer patients receiving radiation therapy or chemoradiation (Level III evidence). A recommendation was made against the use of intravenous glutamine for the prevention of oral mucositis in patients receiving high-dose chemotherapy prior to hematopoietic stem cell transplant (Level II evidence). No guideline was possible for any other agent, due to inadequate and/or conflicting evidence. CONCLUSIONS: Of the various natural agents reviewed here, the available evidence supported a guideline only for two agents: a suggestion in favor of zinc and a recommendation against glutamine, in the treatment settings listed above. Well-designed studies of other natural agents are warranted.
PURPOSE: The aim of this study was to review the available literature and define clinical practice guidelines for the use of natural agents for the prevention and treatment of oral mucositis. METHODS: A systematic review was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology. The body of evidence for each intervention, in each cancer treatment setting, was assigned an evidence level. Based on the evidence level, one of the following three guideline determinations was possible: recommendation, suggestion, and no guideline possible. RESULTS: A total of 49 papers across 15 interventions were examined. A new suggestion was developed in favor of systemic zinc supplements administered orally in the prevention of oral mucositis in oral cancerpatients receiving radiation therapy or chemoradiation (Level III evidence). A recommendation was made against the use of intravenous glutamine for the prevention of oral mucositis in patients receiving high-dose chemotherapy prior to hematopoietic stem cell transplant (Level II evidence). No guideline was possible for any other agent, due to inadequate and/or conflicting evidence. CONCLUSIONS: Of the various natural agents reviewed here, the available evidence supported a guideline only for two agents: a suggestion in favor of zinc and a recommendation against glutamine, in the treatment settings listed above. Well-designed studies of other natural agents are warranted.
Authors: V M Aquino; A R Harvey; J H Garvin; K T Godder; M L Nieder; R H Adams; G B Jackson; E S Sandler Journal: Bone Marrow Transplant Date: 2005-10 Impact factor: 5.483
Authors: P M Anderson; N K Ramsay; X O Shu; N Rydholm; J Rogosheske; R Nicklow; D J Weisdorf; K M Skubitz Journal: Bone Marrow Transplant Date: 1998-08 Impact factor: 5.483
Authors: C Sornsuvit; S Komindr; S Chuncharunee; P Wanikiat; N Archararit; P Santanirand Journal: J Int Med Res Date: 2008 Nov-Dec Impact factor: 1.671
Authors: Letícia de Freitas Cuba; Aroldo Braga Filho; Karen Cherubini; Fernanda Gonçalves Salum; Maria Antonia Zancanaro de Figueiredo Journal: Support Care Cancer Date: 2015-12-23 Impact factor: 3.603
Authors: Siri Beier Jensen; Virginia Jarvis; Yehuda Zadik; Andrei Barasch; Anura Ariyawardana; Allan Hovan; Noam Yarom; Rajesh V Lalla; Joanne Bowen; Sharon Elad Journal: Support Care Cancer Date: 2013-07-31 Impact factor: 3.603
Authors: Ysabella Z A Van Sebille; Romany Stansborough; Hannah R Wardill; Emma Bateman; Rachel J Gibson; Dorothy M Keefe Journal: Curr Oncol Rep Date: 2015-11 Impact factor: 5.075