Literature DB >> 23763543

In vitro reconstitution of the radical S-adenosylmethionine enzyme MqnC involved in the biosynthesis of futalosine-derived menaquinone.

Lisa E Cooper1, Dmytro Fedoseyenko, Sameh H Abdelwahed, Soong-Hyun Kim, Tohru Dairi, Tadhg P Begley.   

Abstract

The radical S-adenosylmethionine enzyme MqnC catalyzes conversion of dehypoxanthine futalosine (DHFL) to the unique spiro compound cyclic DHFL in the futalosine pathway for menaquinone biosynthesis. This study describes the in vitro reconstitution of [4Fe-4S] cluster-dependent MqnC activity and identifies the site of abstraction of a hydrogen atom from DHFL by the adenosyl radical.

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Year:  2013        PMID： 23763543      PMCID： PMC3855634          DOI： 10.1021/bi400498d

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  7 in total

1.  An alternative menaquinone biosynthetic pathway operating in microorganisms.

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Journal:  Science       Date:  2008-09-19       Impact factor: 47.728

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3.  [2Fe-2S] to [4Fe-4S] cluster conversion in Escherichia coli biotin synthase.

Authors:  E C Duin; M E Lafferty; B R Crouse; R M Allen; I Sanyal; D H Flint; M K Johnson
Journal:  Biochemistry       Date:  1997-09-30       Impact factor: 3.162

4.  Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).

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Journal:  Nature       Date:  2002-05-09       Impact factor: 49.962

5.  Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods.

Authors:  H J Sofia; G Chen; B G Hetzler; J F Reyes-Spindola; N E Miller
Journal:  Nucleic Acids Res       Date:  2001-03-01       Impact factor: 16.971

6.  Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily.

Authors:  Kyung-Hoon Lee; Lana Saleh; Brian P Anton; Catherine L Madinger; Jack S Benner; David F Iwig; Richard J Roberts; Carsten Krebs; Squire J Booker
Journal:  Biochemistry       Date:  2009-10-27       Impact factor: 3.162

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Authors:  Petra Hänzelmann; Heather L Hernández; Christian Menzel; Ricardo García-Serres; Boi Hanh Huynh; Michael K Johnson; Ralf R Mendel; Hermann Schindelin
Journal:  J Biol Chem       Date:  2004-06-04       Impact factor: 5.157
  7 in total
  13 in total

Review 1.  Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions.

Authors:  Angad P Mehta; Sameh H Abdelwahed; Nilkamal Mahanta; Dmytro Fedoseyenko; Benjamin Philmus; Lisa E Cooper; Yiquan Liu; Isita Jhulki; Steven E Ealick; Tadhg P Begley
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Review 3.  Enzymatic Cascade Reactions in Biosynthesis.

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7.  Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme.

Authors:  Nilkamal Mahanta; Dmytro Fedoseyenko; Tohru Dairi; Tadhg P Begley
Journal:  J Am Chem Soc       Date:  2013-10-07       Impact factor: 15.419

Review 8.  Enzymatic Transition States and Drug Design.

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Review 9.  C-C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products.

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