Literature DB >> 2374712

A non-curved chicken lysozyme 5' matrix attachment site is 3' followed by a strongly curved DNA sequence.

J P von Kries1, L Phi-Van, S Diekmann, W H Strätling.   

Abstract

Matrix attachment regions (MARs) partition the genome into functional and structural loop-domains. Here, we determined the relative matrix affinity of cloned fragments of the chicken lysozyme 5' MAR. We show that this region contains a non-curved high-affinity binding site, which is 3' followed by a strongly curved DNA sequence that exhibits weak matrix binding. DNA curvature is not a physical property required for strong matrix binding. Possible biological functions of this sequence arrangement, particularly of the strongly curved DNA, are discussed.

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Year:  1990        PMID: 2374712      PMCID: PMC331089          DOI: 10.1093/nar/18.13.3881

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN: 0305-1048            Impact factor:   16.971


  31 in total

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Review 6.  Curved DNA.

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Authors:  P V Loc; W H Strätling
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  19 in total

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10.  Chicken MAR binding protein p120 is identical to human heterogeneous nuclear ribonucleoprotein (hnRNP) U.

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