| Literature DB >> 2374712 |
J P von Kries1, L Phi-Van, S Diekmann, W H Strätling.
Abstract
Matrix attachment regions (MARs) partition the genome into functional and structural loop-domains. Here, we determined the relative matrix affinity of cloned fragments of the chicken lysozyme 5' MAR. We show that this region contains a non-curved high-affinity binding site, which is 3' followed by a strongly curved DNA sequence that exhibits weak matrix binding. DNA curvature is not a physical property required for strong matrix binding. Possible biological functions of this sequence arrangement, particularly of the strongly curved DNA, are discussed.Entities:
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Year: 1990 PMID: 2374712 PMCID: PMC331089 DOI: 10.1093/nar/18.13.3881
Source DB: PubMed Journal: Nucleic Acids Res ISSN: 0305-1048 Impact factor: 16.971