Literature DB >> 23747109

Blocking HIV-1 gp120 at the Phe43 cavity: if the extension fits….

Barna Dey1, Edward A Berger.   

Abstract

The Phe43 cavity is a mysterious feature in crystallographic structures of HIV-1 gp120-CD4 complexes. In this issue of Structure, Acharya and colleagues provide structural explanations for the potent neutralization by CD4 mimetic miniproteins with chemical extensions that fit into this cavity.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23747109      PMCID： PMC3701939          DOI： 10.1016/j.str.2013.05.004

Source DB:  PubMed          Journal:  Structure        ISSN： 0969-2126            Impact factor:   5.006


  11 in total

1.  Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates.

Authors:  P D Kwong; R Wyatt; S Majeed; J Robinson; R W Sweet; J Sodroski; W A Hendrickson
Journal:  Structure       Date:  2000-12-15       Impact factor: 5.006

2.  Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein.

Authors:  Shi-Hua Xiang; Peter D Kwong; Rishi Gupta; Carlo D Rizzuto; David J Casper; Richard Wyatt; Liping Wang; Wayne A Hendrickson; Michael L Doyle; Joseph Sodroski
Journal:  J Virol       Date:  2002-10       Impact factor: 5.103

3.  Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics, and immunogenicity.

Authors:  Barna Dey; Marie Pancera; Krisha Svehla; Yuuei Shu; Shi-Hua Xiang; Jeffrey Vainshtein; Yuxing Li; Joseph Sodroski; Peter D Kwong; John R Mascola; Richard Wyatt
Journal:  J Virol       Date:  2007-03-14       Impact factor: 5.103

4.  CD4 mimetic miniproteins: potent anti-HIV compounds with promising activity as microbicides.

Authors:  Yven Van Herrewege; Laurence Morellato; Anne Descours; Laetitia Aerts; Jo Michiels; Leo Heyndrickx; Loïc Martin; Guido Vanham
Journal:  J Antimicrob Chemother       Date:  2008-02-12       Impact factor: 5.790

Review 5.  Novel miniproteins engineered by the transfer of active sites to small natural scaffolds.

Authors:  C Vita; J Vizzavona; E Drakopoulou; S Zinn-Justin; B Gilquin; A Ménez
Journal:  Biopolymers       Date:  1998       Impact factor: 2.505

6.  Rational design of a CD4 mimic that inhibits HIV-1 entry and exposes cryptic neutralization epitopes.

Authors:  Loïc Martin; François Stricher; Dorothée Missé; Francesca Sironi; Martine Pugnière; Philippe Barthe; Rafael Prado-Gotor; Isabelle Freulon; Xavier Magne; Christian Roumestand; André Ménez; Paolo Lusso; Francisco Veas; Claudio Vita
Journal:  Nat Biotechnol       Date:  2002-12-16       Impact factor: 54.908

7.  Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1.

Authors:  Francesca Curreli; Spreeha Choudhury; Ilya Pyatkin; Victor P Zagorodnikov; Anna Khulianova Bulay; Andrea Altieri; Young Do Kwon; Peter D Kwong; Asim K Debnath
Journal:  J Med Chem       Date:  2012-05-10       Impact factor: 7.446

8.  Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody.

Authors:  P D Kwong; R Wyatt; J Robinson; R W Sweet; J Sodroski; W A Hendrickson
Journal:  Nature       Date:  1998-06-18       Impact factor: 49.962

9.  Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.

Authors:  Navid Madani; Arne Schön; Amy M Princiotto; Judith M Lalonde; Joel R Courter; Takahiro Soeta; Danny Ng; Liping Wang; Evan T Brower; Shi-Hua Xiang; Young Do Kwon; Chih-Chin Huang; Richard Wyatt; Peter D Kwong; Ernesto Freire; Amos B Smith; Joseph Sodroski
Journal:  Structure       Date:  2008-11-12       Impact factor: 5.006

10.  MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques.

Authors:  Nathalie Dereuddre-Bosquet; Laurence Morellato-Castillo; Joachim Brouwers; Patrick Augustijns; Kawthar Bouchemal; Gilles Ponchel; Oscar H P Ramos; Carolina Herrera; Martha Stefanidou; Robin Shattock; Leo Heyndrickx; Guido Vanham; Pascal Kessler; Roger Le Grand; Loïc Martin
Journal:  PLoS Pathog       Date:  2012-12-06       Impact factor: 6.823
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  2 in total

Review 1.  HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth.

Authors:  Priyamvada Acharya; Sabrina Lusvarghi; Carole A Bewley; Peter D Kwong
Journal:  Expert Opin Ther Targets       Date:  2015-02-27       Impact factor: 6.902

2.  Identification of Near-Pan-neutralizing Antibodies against HIV-1 by Deconvolution of Plasma Humoral Responses.

Authors:  Mohammad Mohseni Sajadi; Amir Dashti; Zahra Rikhtegaran Tehrani; William D Tolbert; Michael S Seaman; Xin Ouyang; Neelakshi Gohain; Marzena Pazgier; Dongkyoon Kim; Guy Cavet; Jean Yared; Robert R Redfield; George K Lewis; Anthony L DeVico
Journal:  Cell       Date:  2018-05-03       Impact factor: 41.582
  2 in total

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