Literature DB >> 23733750

Patient-derived tumor xenografts: transforming clinical samples into mouse models.

Despina Siolas1, Gregory J Hannon.   

Abstract

Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with cancer. In addition, these models can be used to study metastasis and tumor genetic evolution. This review examines the development, challenges, and broad use of these attractive preclinical models. ©2013 AACR

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Mesh：

Year:  2013        PMID： 23733750      PMCID： PMC3766500          DOI： 10.1158/0008-5472.CAN-13-1069

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  39 in total

1.  Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients.

Authors:  Tie Chen; Kun Yang; Jianhua Yu; Wentong Meng; Dandan Yuan; Feng Bi; Fang Liu; Jie Liu; Bing Dai; Xinzu Chen; Fang Wang; Fan Zeng; Hong Xu; Jiankun Hu; Xianming Mo
Journal:  Cell Res       Date:  2011-07-05       Impact factor: 25.617

2.  An in vivo platform for translational drug development in pancreatic cancer.

Authors:  Belen Rubio-Viqueira; Antonio Jimeno; George Cusatis; Xianfeng Zhang; Christine Iacobuzio-Donahue; Collins Karikari; Chanjusn Shi; Kathleen Danenberg; Peter V Danenberg; Hidekazu Kuramochi; Koji Tanaka; Sharat Singh; Hossein Salimi-Moosavi; Nadia Bouraoud; Maria L Amador; Soner Altiok; Piotr Kulesza; Charles Yeo; Wells Messersmith; James Eshleman; Ralph H Hruban; Anirban Maitra; Manuel Hidalgo
Journal:  Clin Cancer Res       Date:  2006-08-01       Impact factor: 12.531

3.  Credentialing preclinical pediatric xenograft models using gene expression and tissue microarray analysis.

Authors:  Craig C Whiteford; Sven Bilke; Braden T Greer; Qingrong Chen; Till A Braunschweig; Nicola Cenacchi; Jun S Wei; Malcolm A Smith; Peter Houghton; Christopher Morton; C Patrick Reynolds; Richard Lock; Richard Gorlick; Chand Khanna; Carol J Thiele; Mikiko Takikita; Daniel Catchpoole; Stephen M Hewitt; Javed Khan
Journal:  Cancer Res       Date:  2007-01-01       Impact factor: 12.701

4.  Establishment of human colon cancer cell lines from fresh tumors versus xenografts: comparison of success rate and cell line features.

Authors:  Virginie Dangles-Marie; Marc Pocard; Sophie Richon; Louis-Bastien Weiswald; Franck Assayag; Patrick Saulnier; Jean-Gabriel Judde; Jean-Louis Janneau; Nathalie Auger; Pierre Validire; Bernard Dutrillaux; Françoise Praz; Dominique Bellet; Marie-France Poupon
Journal:  Cancer Res       Date:  2007-01-01       Impact factor: 12.701

5.  Establishment of human tumor xenografts in immunodeficient mice.

Authors:  Christopher L Morton; Peter J Houghton
Journal:  Nat Protoc       Date:  2007       Impact factor: 13.491

Review 6.  Murine models to evaluate novel and conventional therapeutic strategies for cancer.

Authors:  James E Talmadge; Rakesh K Singh; Isaiah J Fidler; Avraham Raz
Journal:  Am J Pathol       Date:  2007-03       Impact factor: 4.307

Review 7.  Contributions of human tumor xenografts to anticancer drug development.

Authors:  Edward A Sausville; Angelika M Burger
Journal:  Cancer Res       Date:  2006-04-01       Impact factor: 12.701

8.  Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomas.

Authors:  I Fichtner; W Slisow; J Gill; M Becker; B Elbe; T Hillebrand; M Bibby
Journal:  Eur J Cancer       Date:  2004-01       Impact factor: 9.162

9.  Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.

Authors:  Panayiotis Loukopoulos; Kengo Kanetaka; Masaaki Takamura; Tatsuhiro Shibata; Michiie Sakamoto; Setsuo Hirohashi
Journal:  Pancreas       Date:  2004-10       Impact factor: 3.327

10.  A new model of patient tumor-derived breast cancer xenografts for preclinical assays.

Authors:  Elisabetta Marangoni; Anne Vincent-Salomon; Nathalie Auger; Armelle Degeorges; Franck Assayag; Patricia de Cremoux; Ludmilla de Plater; Charlotte Guyader; Gonzague De Pinieux; Jean-Gabriel Judde; Magali Rebucci; Carine Tran-Perennou; Xavier Sastre-Garau; Brigitte Sigal-Zafrani; Olivier Delattre; Véronique Diéras; Marie-France Poupon
Journal:  Clin Cancer Res       Date:  2007-07-01       Impact factor: 12.531
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  270 in total

Review 1.  E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution.

Authors:  Dirk Grimm; Sergei Zolotukhin
Journal:  Mol Ther       Date:  2015-09-21       Impact factor: 11.454

Review 2.  Patient-Derived Xenografts as a Model System for Radiation Research.

Authors:  Christopher D Willey; Ashley N Gilbert; Joshua C Anderson; George Yancey Gillespie
Journal:  Semin Radiat Oncol       Date:  2015-05-14       Impact factor: 5.934

Review 3.  Colorectal cancer models for novel drug discovery.

Authors:  Daniel Golovko; Dmitriy Kedrin; Ömer H Yilmaz; Jatin Roper
Journal:  Expert Opin Drug Discov       Date:  2015-08-21       Impact factor: 6.098

4.  Generation of a Liver Orthotopic Human Uveal Melanoma Xenograft Platform in Immunodeficient Mice.

Authors:  Ken Kageyama; Shinji Ozaki; Takami Sato
Journal:  J Vis Exp       Date:  2019-11-06       Impact factor: 1.355

5.  Masked selection: a straightforward and flexible approach for the selection of binders against specific epitopes and differentially expressed proteins by phage display.

Authors:  Klervi Even-Desrumeaux; Damien Nevoltris; Marie Noelle Lavaut; Karima Alim; Jean-Paul Borg; Stéphane Audebert; Brigitte Kerfelec; Daniel Baty; Patrick Chames
Journal:  Mol Cell Proteomics       Date:  2013-12-20       Impact factor: 5.911

Review 6.  Patient-Derived Xenograft Models in Breast Cancer Research.

Authors:  Deukchae Na; Hyeong-Gon Moon
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 7.  Heralding a new paradigm in 3D tumor modeling.

Authors:  Eliza L S Fong; Daniel A Harrington; Mary C Farach-Carson; Hanry Yu
Journal:  Biomaterials       Date:  2016-09-02       Impact factor: 12.479

Review 8.  Challenges and Opportunities for Childhood Cancer Drug Development.

Authors:  Peter J Houghton; Raushan T Kurmasheva
Journal:  Pharmacol Rev       Date:  2019-10       Impact factor: 25.468

Review 9.  Mouse models of cancer-associated thrombosis.

Authors:  Yohei Hisada; Nigel Mackman
Journal:  Thromb Res       Date:  2017-12-29       Impact factor: 3.944

10.  Simultaneous extracellular and intracellular quantification of EGFR using paired-agent imaging in an in ovo tumor model.

Authors:  Kimberley S Samkoe; Emily Schultz; Allison Solanki; Lei Wang; Jesse Korber; Kenneth M Tichauer; Summer L Gibbs
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2019-02-28
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