BACKGROUND: We performed a meta-analysis to compare the accuracy of (18)FDG PET-CT and bone scintigraphy for the detection of bone metastases in breast cancer patients. METHODS: Studies about (18)FDG PET-CT and bone scintigraphy for the detection of bone metastases in breast cancer patients were systematically searched in the MEDLINE and EMBASE databases. We calculated sensitivities, specificities, diagnostic odds ratios, and likelihood ratios, and constructed summary receiver operating characteristic curves using bivariate regression models for (18)FDG PET-CT and bone scintigraphy, respectively. RESULTS: Across 7 studies (668 patients), sensitivity and specificity of PET-CT 0.93 (95% confidence interval [CI] = 0.82-0.98) and 0.99 (95% CI = 0.95-1.00), and of bone scintigraphy were 0.81 (95% CI = 0.58-0.93) and 0.96 (95%CI = 0.76-1.00), respectively. Area under curves for PET-CT and bone scintigraphy was 0.98 (95% CI = 0.98-1.00) and 0.94 (95% CI = 0.92-0.96), respectively. CONCLUSIONS: Compared with bone scintigraphy, (18)FDG PET-CT may higher sensitivity and accuracy for detection of bone metastases in breast cancer patients.
BACKGROUND: We performed a meta-analysis to compare the accuracy of (18)FDG PET-CT and bone scintigraphy for the detection of bone metastases in breast cancerpatients. METHODS: Studies about (18)FDG PET-CT and bone scintigraphy for the detection of bone metastases in breast cancerpatients were systematically searched in the MEDLINE and EMBASE databases. We calculated sensitivities, specificities, diagnostic odds ratios, and likelihood ratios, and constructed summary receiver operating characteristic curves using bivariate regression models for (18)FDG PET-CT and bone scintigraphy, respectively. RESULTS: Across 7 studies (668 patients), sensitivity and specificity of PET-CT 0.93 (95% confidence interval [CI] = 0.82-0.98) and 0.99 (95% CI = 0.95-1.00), and of bone scintigraphy were 0.81 (95% CI = 0.58-0.93) and 0.96 (95%CI = 0.76-1.00), respectively. Area under curves for PET-CT and bone scintigraphy was 0.98 (95% CI = 0.98-1.00) and 0.94 (95% CI = 0.92-0.96), respectively. CONCLUSIONS: Compared with bone scintigraphy, (18)FDG PET-CT may higher sensitivity and accuracy for detection of bone metastases in breast cancerpatients.
Authors: Stephane Zervoudis; George Iatrakis; Eirini Tomara; Anastasia Bothou; George Papadopoulos; George Tsakiris Journal: World J Clin Oncol Date: 2014-08-10
Authors: Basrull N Bhaludin; Nina Tunariu; Dow-Mu Koh; Christina Messiou; Alicia F Okines; Sophie E McGrath; Alistair E Ring; Marina M Parton; Bhupinder Sharma; Tanja Gagliardi; Steven D Allen; Romney Pope; Stephen R D Johnston; Kate Downey Journal: Eur Radiol Date: 2022-04-06 Impact factor: 7.034
Authors: O A Catalano; E Nicolai; B R Rosen; A Luongo; M Catalano; C Iannace; A Guimaraes; M G Vangel; U Mahmood; A Soricelli; M Salvatore Journal: Br J Cancer Date: 2015-04-14 Impact factor: 7.640