BACKGROUND: Diabetes mellitus and low levels of high-density lipoprotein cholesterol (HDL-C) are among several known risk factors for coronary artery disease. Recent research has shown potential mechanistic links between these two diseases. OBJECTIVES: The aim of our study was to characterize, by examining particular coronary artery disease risk factors, patients with extremely high and low levels of HDL-C who were referred to a prevention clinic. METHODS: We compared the phenotypes of 113 patients with HDL-C levels greater than the 90th percentile with 212 patients with levels less than the 10th percentile by using a retrospective chart review. RESULTS: The cohort with high HDL-C had a remarkable difference in the incidence of type 2 diabetes (1.8% vs 21.7%). The high HDL-C cohort also had a greater age (52.1 years vs 46.7 years), more light or moderate alcohol consumption (70.8% vs 49.4%), more healthy diet (30.1% vs 22.4%), more light or moderate exercise (90.8% vs 52.2%), and a lower body mass index (25.2 kg/m² vs 28.1 kg/m²). CONCLUSIONS: Compared with the low HDL-C group--and also the general population--the high HDL-C cohort had a remarkably low prevalence of diabetes mellitus.
BACKGROUND:Diabetes mellitus and low levels of high-density lipoprotein cholesterol (HDL-C) are among several known risk factors for coronary artery disease. Recent research has shown potential mechanistic links between these two diseases. OBJECTIVES: The aim of our study was to characterize, by examining particular coronary artery disease risk factors, patients with extremely high and low levels of HDL-C who were referred to a prevention clinic. METHODS: We compared the phenotypes of 113 patients with HDL-C levels greater than the 90th percentile with 212 patients with levels less than the 10th percentile by using a retrospective chart review. RESULTS: The cohort with high HDL-C had a remarkable difference in the incidence of type 2 diabetes (1.8% vs 21.7%). The high HDL-C cohort also had a greater age (52.1 years vs 46.7 years), more light or moderate alcohol consumption (70.8% vs 49.4%), more healthy diet (30.1% vs 22.4%), more light or moderate exercise (90.8% vs 52.2%), and a lower body mass index (25.2 kg/m² vs 28.1 kg/m²). CONCLUSIONS: Compared with the low HDL-C group--and also the general population--the high HDL-C cohort had a remarkably low prevalence of diabetes mellitus.
Authors: Singh N Sadananda; Jia Nee Foo; Meng Tiak Toh; Lubomira Cermakova; Laia Trigueros-Motos; Teddy Chan; Herty Liany; Jennifer A Collins; Sima Gerami; Roshni R Singaraja; Michael R Hayden; Gordon A Francis; Jiri Frohlich; Chiea Chuen Khor; Liam R Brunham Journal: J Lipid Res Date: 2015-08-08 Impact factor: 5.922
Authors: Julia Jäger; Vera Greiner; Daniela Strzoda; Oksana Seibert; Katharina Niopek; Tjeerd P Sijmonsma; Michaela Schäfer; Allan Jones; Roldan De Guia; Marc Martignoni; Geesje M Dallinga-Thie; Mauricio B Diaz; Thomas G Hofmann; Stephan Herzig Journal: Mol Metab Date: 2014-01-08 Impact factor: 7.422
Authors: Antonino Bianco; Francesco Pomara; Ewan Thomas; Antonio Paoli; Giuseppe Battaglia; Marco Petrucci; Patrizia Proia; Marianna Bellafiore; Antonio Palma Journal: Iran J Public Health Date: 2013-07-01 Impact factor: 1.429
Authors: Michael Schivo; Alexander A Aksenov; Laura C Yeates; Alberto Pasamontes; Cristina E Davis Journal: Front Endocrinol (Lausanne) Date: 2013-11-25 Impact factor: 5.555