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Literature DB >> 23723239

A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C.

Hidenori Kato¹, Jiansheng Jiang, Bing-Rui Zhou, Marieke Rozendaal, Hanqiao Feng, Rodolfo Ghirlando, T Sam Xiao, Aaron F Straight, Yawen Bai.

Abstract

Chromosome segregation during mitosis requires assembly of the kinetochore complex at the centromere. Kinetochore assembly depends on specific recognition of the histone variant CENP-A in the centromeric nucleosome by centromere protein C (CENP-C). We have defined the determinants of this recognition mechanism and discovered that CENP-C binds a hydrophobic region in the CENP-A tail and docks onto the acidic patch of histone H2A and H2B. We further found that the more broadly conserved CENP-C motif uses the same mechanism for CENP-A nucleosome recognition. Our findings reveal a conserved mechanism for protein recruitment to centromeres and a histone recognition mode whereby a disordered peptide binds the histone tail through hydrophobic interactions facilitated by nucleosome docking.

Entities: Chemical Disease Gene Mutation Species

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Year: 2013 PMID： 23723239 PMCID： PMC3763809 DOI： 10.1126/science.1235532

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

28 in total

1. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore.

Authors: Tetsuya Hori; Miho Amano; Aussie Suzuki; Chelsea B Backer; Julie P Welburn; Yimin Dong; Bruce F McEwen; Wei-Hao Shang; Emiko Suzuki; Katsuya Okawa; Iain M Cheeseman; Tatsuo Fukagawa
Journal: Cell Date: 2008-12-12 Impact factor: 41.582

2. Dissection of CENP-C-directed centromere and kinetochore assembly.

Authors: Kirstin J Milks; Ben Moree; Aaron F Straight
Journal: Mol Biol Cell Date: 2009-07-29 Impact factor: 4.138

3. CENP-C functions as a scaffold for effectors with essential kinetochore functions in mitosis and meiosis.

Authors: Koichi Tanaka; Hui Li Chang; Ayano Kagami; Yoshinori Watanabe
Journal: Dev Cell Date: 2009-09 Impact factor: 12.270

4. CENP-C is a structural platform for kinetochore assembly.

Authors: Marcin R Przewloka; Zsolt Venkei; Victor M Bolanos-Garcia; Janusz Debski; Michal Dadlez; David M Glover
Journal: Curr Biol Date: 2011-02-25 Impact factor: 10.834

Review 5. Centromeres: unique chromatin structures that drive chromosome segregation.

Authors: Jolien S Verdaasdonk; Kerry Bloom
Journal: Nat Rev Mol Cell Biol Date: 2011-05 Impact factor: 94.444

6. Epigenetic centromere propagation and the nature of CENP-a nucleosomes.

Authors: Ben E Black; Don W Cleveland
Journal: Cell Date: 2011-02-18 Impact factor: 41.582

7. Dual recognition of CENP-A nucleosomes is required for centromere assembly.

Authors: Christopher W Carroll; Kirstin J Milks; Aaron F Straight
Journal: J Cell Biol Date: 2010-06-21 Impact factor: 10.539

8. Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein.

Authors: R L Cohen; C W Espelin; P De Wulf; P K Sorger; S C Harrison; K T Simons
Journal: Mol Biol Cell Date: 2008-08-13 Impact factor: 4.138

9. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.

Authors: Emanuela Screpanti; Anna De Antoni; Gregory M Alushin; Arsen Petrovic; Tiziana Melis; Eva Nogales; Andrea Musacchio
Journal: Curr Biol Date: 2011-02-25 Impact factor: 10.834

10. Structure of RCC1 chromatin factor bound to the nucleosome core particle.

Authors: Ravindra D Makde; Joseph R England; Hemant P Yennawar; Song Tan
Journal: Nature Date: 2010-08-25 Impact factor: 49.962

166 in total

1. The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.

Authors: Kara L McKinley; Nikolina Sekulic; Lucie Y Guo; Tonia Tsinman; Ben E Black; Iain M Cheeseman
Journal: Mol Cell Date: 2015-11-19 Impact factor: 17.970

2. Homodimeric PHD Domain-containing Rco1 Subunit Constitutes a Critical Interaction Hub within the Rpd3S Histone Deacetylase Complex.

Authors: Chun Ruan; Haochen Cui; Chul-Hwan Lee; Sheng Li; Bing Li
Journal: J Biol Chem Date: 2016-01-08 Impact factor: 5.157

Review 3. Touch, act and go: landing and operating on nucleosomes.

Authors: Valentina Speranzini; Simona Pilotto; Titia K Sixma; Andrea Mattevi
Journal: EMBO J Date: 2016-01-19 Impact factor: 11.598

Review 4. The right place at the right time: chaperoning core histone variants.

Authors: Francesca Mattiroli; Sheena D'Arcy; Karolin Luger
Journal: EMBO Rep Date: 2015-10-12 Impact factor: 8.807

5. Swapping CENP-A at the centromere.

Authors: Bradley T French; Aaron F Straight
Journal: Nat Cell Biol Date: 2013-09 Impact factor: 28.824

6. Structural basis for histone H2B deubiquitination by the SAGA DUB module.

Authors: Michael T Morgan; Mahmood Haj-Yahya; Alison E Ringel; Prasanthi Bandi; Ashraf Brik; Cynthia Wolberger
Journal: Science Date: 2016-02-12 Impact factor: 47.728

7. Structures of CENP-C cupin domains at regional centromeres reveal unique patterns of dimerization and recruitment functions for the inner pocket.

Authors: Jennifer K Chik; Vera Moiseeva; Pavitra K Goel; Ben A Meinen; Philipp Koldewey; Sojin An; Barbara G Mellone; Lakxmi Subramanian; Uhn-Soo Cho
Journal: J Biol Chem Date: 2019-07-31 Impact factor: 5.157

Review 8. Nucleosome structure and dynamics are coming of age.

Authors: Keda Zhou; Guillaume Gaullier; Karolin Luger
Journal: Nat Struct Mol Biol Date: 2018-12-10 Impact factor: 15.369

Review 9. The kinetochore.

Authors: Iain M Cheeseman
Journal: Cold Spring Harb Perspect Biol Date: 2014-07-01 Impact factor: 10.005

Review 10. The centromere: epigenetic control of chromosome segregation during mitosis.

Authors: Frederick G Westhorpe; Aaron F Straight
Journal: Cold Spring Harb Perspect Biol Date: 2014-11-20 Impact factor: 10.005