Bertram Yuh1, Walter Artibani2, Axel Heidenreich3, Simon Kimm4, Mani Menon5, Giacomo Novara6, Ashutosh Tewari7, Karim Touijer4, Timothy Wilson8, Kevin C Zorn9, Scott E Eggener10. 1. City of Hope Cancer Center, Duarte, CA, USA. Electronic address: byuh@coh.org. 2. University Hospital of Verona, Verona, Italy. 3. University of Aachen, Aachen, Germany. 4. Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 5. Henry Ford Hospital, Detroit, MI, USA. 6. University of Padua, Padua, Italy. 7. Weill Cornell Medical College, New York, NY, USA. 8. City of Hope Cancer Center, Duarte, CA, USA. 9. University of Montreal Hospital Center, Montreal, Canada. 10. University of Chicago Medicine and Biological Sciences, Chicago, IL, USA.
Abstract
CONTEXT: The role of robot-assisted radical prostatectomy (RARP) for men with high-risk (HR) prostate cancer (PCa) has not been well studied. OBJECTIVE: To evaluate the indications for surgical treatment, technical aspects such as nerve sparing (NS) and lymph node dissection (LND), and perioperative outcomes of men with HR PCa treated with RARP. EVIDENCE ACQUISITION: A systematic expert review of the literature was performed in October 2012, searching the Medline, Web of Science, and Scopus databases. Studies with a precise HR definition, robotic focus, and reporting of perioperative and pathologic outcomes were included. EVIDENCE SYNTHESIS: A total of 12 papers (1360 patients) evaluating RARP in HR PCa were retrieved. Most studies (67%) used the D'Amico classification for defining HR. Biopsy Gleason grade 8-10 was the most frequent HR identifier (61%). Length of follow-up ranged from 9.7 to 37.7 mo. Incidence of NS varied, although when performed did not appear to compromise oncologic outcomes. Extended LND (ELND) revealed positive nodes in up to a third of patients. The rate of symptomatic lymphocele after ELND was 3%. Overall mean operative time was 168 min, estimated blood loss was 189 ml, length of hospital stay was 3.2 d, and catheterization time was 7.8 d. The 12-mo continence rates using a no-pad definition ranged from 51% to 95% with potency recovery ranging from 52% to 60%. The rate of organ-confined disease was 35%, and the positive margin rate was 35%. Three-year biochemical recurrence-free survival ranged from 45% to 86%. CONCLUSIONS: Although the use of RARP for HR PCa has been relatively limited, it appears safe and effective for select patients. Short-term results are similar to the literature on open radical prostatectomy. Variability exists for NS and the template of LND, although ELND improves staging and removes a higher number of metastatic nodes. Further study is required to assess long-term outcomes.
CONTEXT: The role of robot-assisted radical prostatectomy (RARP) for men with high-risk (HR) prostate cancer (PCa) has not been well studied. OBJECTIVE: To evaluate the indications for surgical treatment, technical aspects such as nerve sparing (NS) and lymph node dissection (LND), and perioperative outcomes of men with HR PCa treated with RARP. EVIDENCE ACQUISITION: A systematic expert review of the literature was performed in October 2012, searching the Medline, Web of Science, and Scopus databases. Studies with a precise HR definition, robotic focus, and reporting of perioperative and pathologic outcomes were included. EVIDENCE SYNTHESIS: A total of 12 papers (1360 patients) evaluating RARP in HR PCa were retrieved. Most studies (67%) used the D'Amico classification for defining HR. Biopsy Gleason grade 8-10 was the most frequent HR identifier (61%). Length of follow-up ranged from 9.7 to 37.7 mo. Incidence of NS varied, although when performed did not appear to compromise oncologic outcomes. Extended LND (ELND) revealed positive nodes in up to a third of patients. The rate of symptomatic lymphocele after ELND was 3%. Overall mean operative time was 168 min, estimated blood loss was 189 ml, length of hospital stay was 3.2 d, and catheterization time was 7.8 d. The 12-mo continence rates using a no-pad definition ranged from 51% to 95% with potency recovery ranging from 52% to 60%. The rate of organ-confined disease was 35%, and the positive margin rate was 35%. Three-year biochemical recurrence-free survival ranged from 45% to 86%. CONCLUSIONS: Although the use of RARP for HR PCa has been relatively limited, it appears safe and effective for select patients. Short-term results are similar to the literature on open radical prostatectomy. Variability exists for NS and the template of LND, although ELND improves staging and removes a higher number of metastatic nodes. Further study is required to assess long-term outcomes.
Authors: Anup Kumar; Srinivas Samavedi; Anthony S Bates; Vladimir Mouraviev; Rafael F Coelho; Bernardo Rocco; Vipul R Patel Journal: J Robot Surg Date: 2016-07-19
Authors: Antonio Benito Porcaro; Marco Sebben; Alessandro Tafuri; Nicolò de Luyk; Paolo Corsi; Tania Processali; Marco Pirozzi; Riccardo Rizzetto; Nelia Amigoni; Daniele Mattevi; Maria A Cerruto; Matteo Brunelli; Giovanni Novella; Vincenzo De Marco; Filippo Migliorini; Walter Artibani Journal: J Robot Surg Date: 2018-05-08
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