BACKGROUND: Intraoperative identification of parathyroid adenomas can be challenging. We hypothesized that low-doses methylene blue (MB) and near-infrared fluorescence (NIRF) imaging could be used to identify parathyroid adenomas intraoperatively. METHODS: MB was injected intravenously after exploration at a dose of 0.5 mg/kg into 12 patients who underwent parathyroid surgery. NIRF imaging was performed using the Mini-FLARE imaging system. RESULTS: In 10 of 12 patients, histology confirmed a parathyroid adenoma. In 9 of these patients, NIRF could clearly identify the parathyroid adenoma during surgery. Seven of these 9 patients had a positive preoperative (99m) Tc-sestamibi single photon emission CT (SPECT) scan. Importantly, in 2 patients, parathyroid adenomas could be identified only using NIRF. CONCLUSION: This is the first study to show that low-dose MB can be used as NIRF tracer for identification of parathyroid adenomas, and suggests a correlation with preoperative (99m) Tc-sestamibi SPECT scanning.
BACKGROUND: Intraoperative identification of parathyroid adenomas can be challenging. We hypothesized that low-doses methylene blue (MB) and near-infrared fluorescence (NIRF) imaging could be used to identify parathyroid adenomas intraoperatively. METHODS:MB was injected intravenously after exploration at a dose of 0.5 mg/kg into 12 patients who underwent parathyroid surgery. NIRF imaging was performed using the Mini-FLARE imaging system. RESULTS: In 10 of 12 patients, histology confirmed a parathyroid adenoma. In 9 of these patients, NIRF could clearly identify the parathyroid adenoma during surgery. Seven of these 9 patients had a positive preoperative (99m) Tc-sestamibi single photon emission CT (SPECT) scan. Importantly, in 2 patients, parathyroid adenomas could be identified only using NIRF. CONCLUSION: This is the first study to show that low-dose MB can be used as NIRF tracer for identification of parathyroid adenomas, and suggests a correlation with preoperative (99m) Tc-sestamibi SPECT scanning.
Authors: Merlijn Hutteman; Joost R van der Vorst; Katja N Gaarenstroom; Alexander A W Peters; J Sven D Mieog; Boudewijn E Schaafsma; Clemens W G M Löwik; John V Frangioni; Cornelis J H van de Velde; Alexander L Vahrmeijer Journal: Am J Obstet Gynecol Date: 2011-07-30 Impact factor: 8.661
Authors: Merlijn Hutteman; Hak Soo Choi; J Sven D Mieog; Joost R van der Vorst; Yoshitomo Ashitate; Peter J K Kuppen; Marian C van Groningen; Clemens W G M Löwik; Vincent T H B M Smit; Cornelis J H van de Velde; John V Frangioni; Alexander L Vahrmeijer Journal: Ann Surg Oncol Date: 2010-11-16 Impact factor: 5.344
Authors: Stijn Keereweer; Jeroen D F Kerrebijn; Pieter B A A van Driel; Bangwen Xie; Eric L Kaijzel; Thomas J A Snoeks; Ivo Que; Merlijn Hutteman; Joost R van der Vorst; J Sven D Mieog; Alexander L Vahrmeijer; Cornelis J H van de Velde; Robert J Baatenburg de Jong; Clemens W G M Löwik Journal: Mol Imaging Biol Date: 2011-04 Impact factor: 3.488
Authors: Lucia M A Crane; George Themelis; Rick G Pleijhuis; Niels J Harlaar; Athanasios Sarantopoulos; Henriette J G Arts; Ate G J van der Zee; Vasilis Ntziachristos; Ntziachristos Vasilis; Gooitzen M van Dam Journal: Mol Imaging Biol Date: 2011-10 Impact factor: 3.488
Authors: Ava Hosseini; Jennifer L Baker; Christopher A Tokin; Zhengtao Qin; David J Hall; Dwayne G Stupak; Tomoko Hayashi; Anne M Wallace; David R Vera Journal: J Surg Res Date: 2014-05-10 Impact factor: 2.192
Authors: Ray R Zhang; Alexandra B Schroeder; Joseph J Grudzinski; Eben L Rosenthal; Jason M Warram; Anatoly N Pinchuk; Kevin W Eliceiri; John S Kuo; Jamey P Weichert Journal: Nat Rev Clin Oncol Date: 2017-01-17 Impact factor: 66.675
Authors: Q R J G Tummers; F P R Verbeek; B E Schaafsma; M C Boonstra; J R van der Vorst; G-J Liefers; C J H van de Velde; J V Frangioni; A L Vahrmeijer Journal: Eur J Surg Oncol Date: 2014-02-22 Impact factor: 4.424
Authors: Roland Ladurner; Sandra Sommerey; Nora Al Arabi; Klaus K J Hallfeldt; Herbert Stepp; Julia K S Gallwas Journal: Surg Endosc Date: 2016-11-14 Impact factor: 4.584