L Yang1, W J M Udall, E V McCloskey, R Eastell. 1. Academic Unit of Bone Metabolism, Mellanby Centre for Bone Research, School of Medicine, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK, l.yang@sheffield.ac.uk.
Abstract
UNLABELLED: The quantitative computed tomography (QCT) scans in an individually matched case-control study of women with hip fracture were analysed. There were widespread deficits in the femoral volumetric bone mineral density (vBMD) and cortical thickness of cases, and cortical vBMD and thickness discriminated hip fracture independently of BMD by dual-energy X-ray absorptiometry (DXA). INTRODUCTION: Acknowledging the limitations of QCT associated with partial volume effects, we used QCT in an individually matched case-control study of women with hip fracture to better understand its structural basis. METHODS: Fifty postmenopausal women (55-89 years) who had sustained hip fractures due to low-energy trauma underwent QCT scans of the contralateral hip within 3 months of the fracture. For each case, postmenopausal women, matched by age (±5 years), weight (±5 kg) and height (±5 cm), were recruited as controls. We quantified cortical, trabecular and integral vBMD and apparent cortical thickness (AppCtTh) in four quadrants of cross-sections along the length of the femoral head (FH), femoral neck (FN), intertrochanter and trochanter and examined their association with hip fracture. RESULTS: Women with hip or intracapsular (IC) fracture had significantly (p < 0.05) lower vBMD and AppCtTh than the controls in the majority of cross-sections and quadrants of the proximal femur, and both cortical and trabecular compartments are involved. Cortical vBMD and AppCtTh in the FH and FN were associated with hip and IC fractures independent of hip areal BMD (aBMD). The combination of AppCtTh and trabecular or integral vBMD discriminated hip fracture, whereas the combination of FH and FN AppCtTh discriminated IC fracture significantly (p < 0.05) better than the hip aBMD. CONCLUSION: Deficits in vBMD and AppCtTh in cases were widespread in the proximal femur, and cortical vBMD and AppCtTh discriminated hip fracture independently of aBMD by DXA.
UNLABELLED: The quantitative computed tomography (QCT) scans in an individually matched case-control study of women with hip fracture were analysed. There were widespread deficits in the femoral volumetric bone mineral density (vBMD) and cortical thickness of cases, and cortical vBMD and thickness discriminated hip fracture independently of BMD by dual-energy X-ray absorptiometry (DXA). INTRODUCTION: Acknowledging the limitations of QCT associated with partial volume effects, we used QCT in an individually matched case-control study of women with hip fracture to better understand its structural basis. METHODS: Fifty postmenopausal women (55-89 years) who had sustained hip fractures due to low-energy trauma underwent QCT scans of the contralateral hip within 3 months of the fracture. For each case, postmenopausal women, matched by age (±5 years), weight (±5 kg) and height (±5 cm), were recruited as controls. We quantified cortical, trabecular and integral vBMD and apparent cortical thickness (AppCtTh) in four quadrants of cross-sections along the length of the femoral head (FH), femoral neck (FN), intertrochanter and trochanter and examined their association with hip fracture. RESULTS: Women with hip or intracapsular (IC) fracture had significantly (p < 0.05) lower vBMD and AppCtTh than the controls in the majority of cross-sections and quadrants of the proximal femur, and both cortical and trabecular compartments are involved. Cortical vBMD and AppCtTh in the FH and FN were associated with hip and IC fractures independent of hip areal BMD (aBMD). The combination of AppCtTh and trabecular or integral vBMD discriminated hip fracture, whereas the combination of FH and FN AppCtTh discriminated IC fracture significantly (p < 0.05) better than the hip aBMD. CONCLUSION: Deficits in vBMD and AppCtTh in cases were widespread in the proximal femur, and cortical vBMD and AppCtTh discriminated hip fracture independently of aBMD by DXA.
Authors: Eva-Maria Lochmüller; Ralph Müller; Volker Kuhn; Christoph A Lill; Felix Eckstein Journal: J Bone Miner Res Date: 2003-05 Impact factor: 6.741
Authors: Roger M D Zebaze; Ali Ghasem-Zadeh; Ann Bohte; Sandra Iuliano-Burns; Michiko Mirams; Roger Ian Price; Eleanor J Mackie; Ego Seeman Journal: Lancet Date: 2010-05-15 Impact factor: 79.321
Authors: Jörn Rittweger; Gisela Beller; Gabriele Armbrecht; Edwin Mulder; Björn Buehring; Ulf Gast; Fernando Dimeo; Harald Schubert; Arnold de Haan; Dick F Stegeman; Hans Schiessl; Dieter Felsenberg Journal: Bone Date: 2009-09-02 Impact factor: 4.398
Authors: Lynn M Marshall; Thomas F Lang; Lori C Lambert; Joseph M Zmuda; Kristine E Ensrud; Eric S Orwoll Journal: J Bone Miner Res Date: 2006-08 Impact factor: 6.741
Authors: S C E Schuit; M van der Klift; A E A M Weel; C E D H de Laet; H Burger; E Seeman; A Hofman; A G Uitterlinden; J P T M van Leeuwen; H A P Pols Journal: Bone Date: 2004-01 Impact factor: 4.398
Authors: R Eastell; T Lang; S Boonen; S Cummings; P D Delmas; J A Cauley; Z Horowitz; E Kerzberg; G Bianchi; D Kendler; P Leung; Z Man; P Mesenbrink; E F Eriksen; D M Black Journal: Osteoporos Int Date: 2009-10-03 Impact factor: 4.507
Authors: C David L Thomas; Paul M Mayhew; Jon Power; Kenneth Es Poole; Nigel Loveridge; John G Clement; Chris J Burgoyne; Jonathan Reeve Journal: J Bone Miner Res Date: 2009-11 Impact factor: 6.741
Authors: L Wang; X G Cheng; Y B Su; K Brown; L Xu; K Li; C X Zhang; Y Zhang; Y Y Duanmu; X B Wu; M Y Wang Journal: Osteoporos Int Date: 2017-04-12 Impact factor: 4.507
Authors: Julio Carballido-Gamio; Aihong Yu; Ling Wang; Yongbin Su; Andrew J Burghardt; Thomas F Lang; Xiaoguang Cheng Journal: Ann Biomed Eng Date: 2019-05-31 Impact factor: 3.934
Authors: Cheng Li; Dakai Jin; Cheng Chen; Elena M Letuchy; Kathleen F Janz; Trudy L Burns; James C Torner; Steven M Levy; Punam K Saha Journal: Med Phys Date: 2015-08 Impact factor: 4.071
Authors: Jan Borggrefe; Timm de Buhr; Smriti Shrestha; Lynn M Marshall; Eric Orwoll; Kathy Peters; Dennis M Black; Claus C Glüer Journal: J Bone Miner Res Date: 2016-05-04 Impact factor: 6.741