AIM: This study aimed to identify predictive/prognostic factors in castration-resistant prostate cancer patients treated with cabazitaxel. PATIENTS & METHODS: Patients were enrolled from March 2011 to December 2011 in an international expanded access program. In January 2012, when cabazitaxel became commercially available, a prospective study was initiated at University Federico II of Naples and at Rionero in Vulture Hospital. RESULTS: Forty-seven patients were enrolled in this study. Patients received a median of nine cycles of cabazitaxel. Median progression-free survival was 7.0 months (95% CI: 5.7-8.0). Seventeen patients were still alive at the time of the analysis, with a median overall survival of 14 months (95% CI: 11-16). At multivariate analysis, a higher Gleason score (≥ 8) appeared to be associated with prolonged progression-free survival (hazard ratio: 0.36; 95% CI: 0.18-0.72); however, the higher Gleason score showed no statistical impact on overall survival. CONCLUSION: We hypothesize that the Gleason score has the potential to be incorporated in the clinical decision-making process for definition of treatment strategy in docetaxel-pretreated castration-resistant prostate cancer patients. We encourage further experimentation in this setting.
AIM: This study aimed to identify predictive/prognostic factors in castration-resistant prostate cancerpatients treated with cabazitaxel. PATIENTS & METHODS:Patients were enrolled from March 2011 to December 2011 in an international expanded access program. In January 2012, when cabazitaxel became commercially available, a prospective study was initiated at University Federico II of Naples and at Rionero in Vulture Hospital. RESULTS: Forty-seven patients were enrolled in this study. Patients received a median of nine cycles of cabazitaxel. Median progression-free survival was 7.0 months (95% CI: 5.7-8.0). Seventeen patients were still alive at the time of the analysis, with a median overall survival of 14 months (95% CI: 11-16). At multivariate analysis, a higher Gleason score (≥ 8) appeared to be associated with prolonged progression-free survival (hazard ratio: 0.36; 95% CI: 0.18-0.72); however, the higher Gleason score showed no statistical impact on overall survival. CONCLUSION: We hypothesize that the Gleason score has the potential to be incorporated in the clinical decision-making process for definition of treatment strategy in docetaxel-pretreated castration-resistant prostate cancerpatients. We encourage further experimentation in this setting.
Authors: Daniel W Yokom; John Stewart; Nimira S Alimohamed; Eric Winquist; Scott Berry; Stacey Hubay; Jean-Baptiste Lattouf; Helene Leonard; Carla Girolametto; Fred Saad; Srikala S Sridhar Journal: Can Urol Assoc J Date: 2018-04-06 Impact factor: 1.862
Authors: Giuseppe Di Lorenzo; Martina Pagliuca; Teresa Perillo; Alfonso Benincasa; Davide Bosso; Sabino De Placido; Carlo Buonerba Journal: Medicine (Baltimore) Date: 2016-04 Impact factor: 1.889
Authors: William K Oh; Raymond Miao; Francis Vekeman; Jennifer Sung; Wendy Y Cheng; Marjolaine Gauthier-Loiselle; Ravinder Dhawan; Mei Sheng Duh Journal: Med Oncol Date: 2017-08-10 Impact factor: 3.064