Daniel W Yokom1, John Stewart2, Nimira S Alimohamed3, Eric Winquist4, Scott Berry5, Stacey Hubay6, Jean-Baptiste Lattouf7, Helene Leonard8, Carla Girolametto6, Fred Saad7, Srikala S Sridhar1. 1. Princess Margaret Cancer Centre, Toronto, ON, Canada. 2. Sanofi Canada, Montreal, QC, Canada. 3. Tom Baker Cancer Centre, Calgary, ON, Canada. 4. London Health Sciences Centre, London, ON, Canada. 5. Sunnybrook Health Sciences Centre, Odette Cancer Centre, Toronto, ON, Canada. 6. Grand River Regional Cancer Centre, Kitchener, ON, Canada. 7. Division or Urology, Centre Hospitalier de l'Université de Montréal (CHUM), Montreal, QC, Canada. 8. CHUM Notre-Dame Hospital, Montreal, QC, Canada.
Abstract
INTRODUCTION: Cabazitaxel is one of several treatment options available for patients with metastatic castration-resistant prostate cancer who have progressed on docetaxel. Little is known about clinical factors that influence prognosis or treatment response for patients receiving cabazitaxel. Identifying prognostic and predictive factors could contribute to the optimal selection of patients for treatment after docetaxel. METHODS: A retrospective review of patients enrolled on the cabazitaxel Canadian Early Access Program (C-EAP) was performed. Clinical factors were analyzed by univariable and multivariable Cox proportional hazards and logistic regression analysis to identify independent predictors of prognosis and response. RESULTS: Forty-five patients from five centres in Canada were included in this study. On multivariable analysis, lower hemoglobin was associated with shorter survival. No other factors were independently associated with survival, prostate-specific antigen (PSA) response, or primary PSA progression. CONCLUSIONS: Clinical factors predicting survival or treatment response were not identified for men with castration-resistant prostate cancer receiving cabazitaxel. Larger studies may be necessary to identify clinical factors and biomarkers that identify whether patients should or should not receive cabazitaxel.
INTRODUCTION:Cabazitaxel is one of several treatment options available for patients with metastatic castration-resistant prostate cancer who have progressed on docetaxel. Little is known about clinical factors that influence prognosis or treatment response for patients receiving cabazitaxel. Identifying prognostic and predictive factors could contribute to the optimal selection of patients for treatment after docetaxel. METHODS: A retrospective review of patients enrolled on the cabazitaxel Canadian Early Access Program (C-EAP) was performed. Clinical factors were analyzed by univariable and multivariable Cox proportional hazards and logistic regression analysis to identify independent predictors of prognosis and response. RESULTS: Forty-five patients from five centres in Canada were included in this study. On multivariable analysis, lower hemoglobin was associated with shorter survival. No other factors were independently associated with survival, prostate-specific antigen (PSA) response, or primary PSA progression. CONCLUSIONS: Clinical factors predicting survival or treatment response were not identified for men with castration-resistant prostate cancer receiving cabazitaxel. Larger studies may be necessary to identify clinical factors and biomarkers that identify whether patients should or should not receive cabazitaxel.
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