| Literature DB >> 23715428 |
Jonel P Saludes1, Leslie A Morton, Sara K Coulup, Zeno Fiorini, Brandan M Cook, Lida Beninson, Edwin R Chapman, Monika Fleshner, Hang Yin.
Abstract
The trimer of a bradykinin derivative displayed a more than five-fold increase in binding affinity for phosphatidylserine-enriched nanovesicles as compared to its monomeric precursor. The nanovesicle selection is directly correlated with multivalency, which amplifies the electrostatic attraction. This strategy may lead to the development of novel molecular probes for detecting highly curved membrane bilayers.Entities:
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Year: 2013 PMID： 23715428 PMCID： PMC3764994 DOI： 10.1039/c3mb70109c
Source DB: PubMed Journal: Mol Biosyst ISSN： 1742-2051