Literature DB >> 23712313

Genetics and alcoholism.

Howard J Edenberg1, Tatiana Foroud.   

Abstract

Alcohol is widely consumed; however, excessive use creates serious physical, psychological and social problems and contributes to the pathogenesis of many diseases. Alcohol use disorders (that is, alcohol dependence and alcohol abuse) are maladaptive patterns of excessive drinking that lead to serious problems. Abundant evidence indicates that alcohol dependence (alcoholism) is a complex genetic disease, with variations in a large number of genes affecting a person's risk of alcoholism. Some of these genes have been identified, including two genes involved in the metabolism of alcohol (ADH1B and ALDH2) that have the strongest known affects on the risk of alcoholism. Studies continue to reveal other genes in which variants affect the risk of alcoholism or related traits, including GABRA2, CHRM2, KCNJ6 and AUTS2. As more variants are analysed and studies are combined for meta-analysis to achieve increased sample sizes, an improved picture of the many genes and pathways that affect the risk of alcoholism will be possible.

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Year:  2013        PMID： 23712313      PMCID： PMC4056340          DOI： 10.1038/nrgastro.2013.86

Source DB:  PubMed          Journal:  Nat Rev Gastroenterol Hepatol        ISSN： 1759-5045            Impact factor:   46.802


  81 in total

1.  DSM-IV to DSM-5: the impact of proposed revisions on diagnosis of alcohol use disorders.

Authors:  Arpana Agrawal; Andrew C Heath; Michael T Lynskey
Journal:  Addiction       Date:  2011-08-18       Impact factor: 6.526

2.  Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism.

Authors:  S Villafuerte; M M Heitzeg; S Foley; W-Y Wendy Yau; K Majczenko; J-K Zubieta; R A Zucker; M Burmeister
Journal:  Mol Psychiatry       Date:  2011-04-12       Impact factor: 15.992

3.  An evaluation of the proposed DSM-5 alcohol use disorder criteria using Australian national data.

Authors:  Louise Mewton; Tim Slade; Orla McBride; Rachel Grove; Maree Teesson
Journal:  Addiction       Date:  2011-03-07       Impact factor: 6.526

4.  Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians.

Authors:  Dawei Li; Hongyu Zhao; Joel Gelernter
Journal:  Hum Genet       Date:  2011-11-20       Impact factor: 4.132

5.  GABRG1 and GABRA2 variation associated with alcohol dependence in African Americans.

Authors:  Chupong Ittiwut; Bao-Zhu Yang; Henry R Kranzler; Raymond F Anton; Rungnapa Hirunsatit; Roger D Weiss; Jonathan Covault; Lindsay A Farrer; Joel Gelernter
Journal:  Alcohol Clin Exp Res       Date:  2011-09-15       Impact factor: 3.455

6.  Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence.

Authors:  G J Lydall; J Saini; K Ruparelia; S Montagnese; A McQuillin; I Guerrini; H Rao; G Reynolds; D Ball; I Smith; A D Thomson; M Y Morgan; H M D Gurling
Journal:  Neurosci Lett       Date:  2011-06-12       Impact factor: 3.046

7.  Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.

Authors:  S J Kang; M Rangaswamy; N Manz; J-C Wang; L Wetherill; T Hinrichs; L Almasy; A Brooks; D B Chorlian; D Dick; V Hesselbrock; J Kramer; S Kuperman; J Nurnberger; J Rice; M Schuckit; J Tischfield; L J Bierut; H J Edenberg; A Goate; T Foroud; B Porjesz
Journal:  Genes Brain Behav       Date:  2012-05-31       Impact factor: 3.449

8.  Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.

Authors:  Gunter Schumann; Lachlan J Coin; Anbarasu Lourdusamy; Pimphen Charoen; Karen H Berger; David Stacey; Sylvane Desrivières; Fazil A Aliev; Anokhi A Khan; Najaf Amin; Yurii S Aulchenko; Georgy Bakalkin; Stephan J Bakker; Beverley Balkau; Joline W Beulens; Ainhoa Bilbao; Rudolf A de Boer; Delphine Beury; Michiel L Bots; Elemi J Breetvelt; Stéphane Cauchi; Christine Cavalcanti-Proença; John C Chambers; Toni-Kim Clarke; Norbert Dahmen; Eco J de Geus; Danielle Dick; Francesca Ducci; Alanna Easton; Howard J Edenberg; Tõnu Esko; Tõnu Esk; Alberto Fernández-Medarde; Tatiana Foroud; Nelson B Freimer; Jean-Antoine Girault; Diederick E Grobbee; Simonetta Guarrera; Daniel F Gudbjartsson; Anna-Liisa Hartikainen; Andrew C Heath; Victor Hesselbrock; Albert Hofman; Jouke-Jan Hottenga; Matti K Isohanni; Jaakko Kaprio; Kay-Tee Khaw; Brigitte Kuehnel; Jaana Laitinen; Stéphane Lobbens; Jian'an Luan; Massimo Mangino; Matthieu Maroteaux; Giuseppe Matullo; Mark I McCarthy; Christian Mueller; Gerjan Navis; Mattijs E Numans; Alejandro Núñez; Dale R Nyholt; Charlotte N Onland-Moret; Ben A Oostra; Paul F O'Reilly; Miklos Palkovits; Brenda W Penninx; Silvia Polidoro; Anneli Pouta; Inga Prokopenko; Fulvio Ricceri; Eugenio Santos; Johannes H Smit; Nicole Soranzo; Kijoung Song; Ulla Sovio; Michael Stumvoll; Ida Surakk; Thorgeir E Thorgeirsson; Unnur Thorsteinsdottir; Claire Troakes; Thorarinn Tyrfingsson; Anke Tönjes; Cuno S Uiterwaal; Andre G Uitterlinden; Pim van der Harst; Yvonne T van der Schouw; Oliver Staehlin; Nicole Vogelzangs; Peter Vollenweider; Gerard Waeber; Nicholas J Wareham; Dawn M Waterworth; John B Whitfield; Erich H Wichmann; Gonneke Willemsen; Jacqueline C Witteman; Xin Yuan; Guangju Zhai; Jing H Zhao; Weihua Zhang; Nicholas G Martin; Andres Metspalu; Angela Doering; James Scott; Tim D Spector; Ruth J Loos; Dorret I Boomsma; Vincent Mooser; Leena Peltonen; Kari Stefansson; Cornelia M van Duijn; Paolo Vineis; Wolfgang H Sommer; Jaspal S Kooner; Rainer Spanagel; Ulrike A Heberlein; Marjo-Riitta Jarvelin; Paul Elliott
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-06       Impact factor: 11.205

9.  ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry.

Authors:  L J Bierut; A M Goate; N Breslau; E O Johnson; S Bertelsen; L Fox; A Agrawal; K K Bucholz; R Grucza; V Hesselbrock; J Kramer; S Kuperman; J Nurnberger; B Porjesz; N L Saccone; M Schuckit; J Tischfield; J C Wang; T Foroud; J P Rice; H J Edenberg
Journal:  Mol Psychiatry       Date:  2011-10-04       Impact factor: 15.992

10.  Genes encoding enzymes involved in ethanol metabolism.

Authors:  Thomas D Hurley; Howard J Edenberg
Journal:  Alcohol Res       Date:  2012
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  59 in total

1.  Differential potassium channel gene regulation in BXD mice reveals novel targets for pharmacogenetic therapies to reduce heavy alcohol drinking.

Authors:  Jennifer A Rinker; Diana B Fulmer; Heather Trantham-Davidson; Maren L Smith; Robert W Williams; Marcelo F Lopez; Patrick K Randall; L Judson Chandler; Michael F Miles; Howard C Becker; Patrick J Mulholland
Journal:  Alcohol       Date:  2016-06-27       Impact factor: 2.405

Review 2.  Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder.

Authors:  Mike Grotewiel; Jill C Bettinger
Journal:  Alcohol Clin Exp Res       Date:  2015-07-14       Impact factor: 3.455

Review 3.  Genetic studies of alcohol dependence in the context of the addiction cycle.

Authors:  Matthew T Reilly; Antonio Noronha; David Goldman; George F Koob
Journal:  Neuropharmacology       Date:  2017-01-22       Impact factor: 5.250

4.  An ADH1B variant and peer drinking in progression to adolescent drinking milestones: evidence of a gene-by-environment interaction.

Authors:  Emily Olfson; Howard J Edenberg; John Nurnberger; Arpana Agrawal; Kathleen K Bucholz; Laura A Almasy; David Chorlian; Danielle M Dick; Victor M Hesselbrock; John R Kramer; Samuel Kuperman; Bernice Porjesz; Marc A Schuckit; Jay A Tischfield; Jen-Chyong Wang; Leah Wetherill; Tatiana M Foroud; John Rice; Alison Goate; Laura J Bierut
Journal:  Alcohol Clin Exp Res       Date:  2014-09-24       Impact factor: 3.455

5.  A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis.

Authors:  Stephan Buch; Felix Stickel; Eric Trépo; Michael Way; Alexander Herrmann; Hans Dieter Nischalke; Mario Brosch; Jonas Rosendahl; Thomas Berg; Monika Ridinger; Marcella Rietschel; Andrew McQuillin; Josef Frank; Falk Kiefer; Stefan Schreiber; Wolfgang Lieb; Michael Soyka; Nasser Semmo; Elmar Aigner; Christian Datz; Renate Schmelz; Stefan Brückner; Sebastian Zeissig; Anna-Magdalena Stephan; Norbert Wodarz; Jacques Devière; Nicolas Clumeck; Christoph Sarrazin; Frank Lammert; Thierry Gustot; Pierre Deltenre; Henry Völzke; Markus M Lerch; Julia Mayerle; Florian Eyer; Clemens Schafmayer; Sven Cichon; Markus M Nöthen; Michael Nothnagel; David Ellinghaus; Klaus Huse; Andre Franke; Steffen Zopf; Claus Hellerbrand; Christophe Moreno; Denis Franchimont; Marsha Y Morgan; Jochen Hampe
Journal:  Nat Genet       Date:  2015-10-19       Impact factor: 38.330

6.  Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity.

Authors:  Irina Balan; Kaitlin T Warnock; Adam Puche; Marjorie C Gondre-Lewis; Laure Aurelian
Journal:  Brain Behav Immun       Date:  2017-11-13       Impact factor: 7.217

7.  Fast Principal-Component Analysis Reveals Convergent Evolution of ADH1B in Europe and East Asia.

Authors:  Kevin J Galinsky; Gaurav Bhatia; Po-Ru Loh; Stoyan Georgiev; Sayan Mukherjee; Nick J Patterson; Alkes L Price
Journal:  Am J Hum Genet       Date:  2016-02-25       Impact factor: 11.025

8.  Genetics of alcohol consumption in Drosophila melanogaster.

Authors:  S Fochler; T V Morozova; M R Davis; A W Gearhart; W Huang; T F C Mackay; R R H Anholt
Journal:  Genes Brain Behav       Date:  2017-07-21       Impact factor: 3.449

9.  Dynamic changes in gene expression and alternative splicing mediate the response to acute alcohol exposure in Drosophila melanogaster.

Authors:  Sarah Signor; Sergey Nuzhdin
Journal:  Heredity (Edinb)       Date:  2018-08-24       Impact factor: 3.821

10.  Alcohol-preferring P rats exhibit aversion-resistant drinking of alcohol adulterated with quinine.

Authors:  Nicholas M Timme; David Linsenbardt; Maureen Timm; Taylor Galbari; Ethan Cornwell; Christopher Lapish
Journal:  Alcohol       Date:  2019-09-19       Impact factor: 2.405
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