| Literature DB >> 26482880 |
Stephan Buch1, Felix Stickel2, Eric Trépo3,4, Michael Way5,6, Alexander Herrmann1, Hans Dieter Nischalke7, Mario Brosch1, Jonas Rosendahl8, Thomas Berg8, Monika Ridinger9,10, Marcella Rietschel11, Andrew McQuillin6, Josef Frank11, Falk Kiefer11, Stefan Schreiber12, Wolfgang Lieb13, Michael Soyka14, Nasser Semmo15, Elmar Aigner16, Christian Datz16, Renate Schmelz1, Stefan Brückner1, Sebastian Zeissig1, Anna-Magdalena Stephan1, Norbert Wodarz9, Jacques Devière3,4, Nicolas Clumeck17, Christoph Sarrazin18, Frank Lammert19, Thierry Gustot3,4, Pierre Deltenre3,20,21, Henry Völzke22, Markus M Lerch23, Julia Mayerle23, Florian Eyer24, Clemens Schafmayer25, Sven Cichon26, Markus M Nöthen27,28, Michael Nothnagel29, David Ellinghaus30, Klaus Huse31, Andre Franke30, Steffen Zopf32, Claus Hellerbrand33, Christophe Moreno3,4, Denis Franchimont3,4, Marsha Y Morgan5, Jochen Hampe1.
Abstract
Alcohol misuse is the leading cause of cirrhosis and the second most common indication for liver transplantation in the Western world. We performed a genome-wide association study for alcohol-related cirrhosis in individuals of European descent (712 cases and 1,426 controls) with subsequent validation in two independent European cohorts (1,148 cases and 922 controls). We identified variants in the MBOAT7 (P = 1.03 × 10(-9)) and TM6SF2 (P = 7.89 × 10(-10)) genes as new risk loci and confirmed rs738409 in PNPLA3 as an important risk locus for alcohol-related cirrhosis (P = 1.54 × 10(-48)) at a genome-wide level of significance. These three loci have a role in lipid processing, suggesting that lipid turnover is important in the pathogenesis of alcohol-related cirrhosis.Entities:
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Year: 2015 PMID： 26482880 DOI： 10.1038/ng.3417
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330